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TranscriptomicsGene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells
Treatment of acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA) results in terminal differentiation of leukemic cells toward neutrophil granulocytes. Administration of ATRA leads to massive changes in gene expression, including down-regulation of cell proliferation-related genes ...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress
TranscriptomicsNB4 cell line treatment with WEB-2170
This study reports the ability of WEB-2170, an antagonist of platelet-activating-factor receptor, to induce apoptosis in human acute myelogenous leukemia (AML) cells. Action mechanisms of WEB-2170 were first investigated in promyelocytic NB4 cells by DNA microarray profiling followed by morphologic...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-12645 | biostudies-arrayexpress
TranscriptomicsEffects of CEBPA isoform expression on NB4 cells
Here we investigated the effects of CEBPA transcription factor expression on myeloid NB4 cells. The sequence of rat CEBPA was C-terminally fused to a promiscuous biotin ligase tag (BirA*) and NB4 cell lines were engineered to express the fusion protein under the control of a doxycycline inducible p...
ORGANISM(S): Homo sapiens 
2021-06-26 | E-MTAB-9947 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ATRA treated NB4 cells
NB4 is an APL derived cell line, carrying the t(15;17) translocation and expressing the PML/RARa fusion protein. Still, an important question that remains to be addressed is whether PML/RARa target genes are transcriptionally suppressed in primary APL cells and re-activated in all-trans retinoic aci...
ORGANISM(S): Homo sapiens 
2009-12-14 | E-GEOD-19201 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing analysis of NB4 cells overexpressing miR-125b
To better understand the mechanisms of blockage of myeloid differentiation and apoptosis and induction of proliferation by miR-125b, we proceeded to identify miR-125b target genes involved in these pathways. We analyzed the total cellular gene expression pattern by RNA-sequencing of the parental NB4...
ORGANISM(S): Homo sapiens 
2012-04-06 | E-GEOD-37061 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human the treatments A. phagocytophilum-infected vs uninfected NB4 cells to determine the global impact of A. phagocytophilum infection in NB4 cells
THREE INDEPENDENT REPLICATES ARE THE CONTROL NON-INFECTED CELLS: GSM49939, GSM49940, GSM49941; THREE INFECTED INDEPEDENDENT REPLICATES: GSM49942, GSM49943, GSM49944
ORGANISM(S): Homo sapiens 
2007-09-08 | E-GEOD-2600 | biostudies-arrayexpress
TranscriptomicsGene expression profiling during Ara-C induced NB4 cell apoptosis
As the most important antimetabolite used to induce remission in children and adults with acute leukemia, cytosine arabinoside (Ara-C) is widely used in consolidation therapy of APL to reduce the relapse rate. In order to better understand the molecular mechanism underlying Ara-C induced cell early ...
ORGANISM(S): Homo sapiens 
2011-10-14 | E-GEOD-32992 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling of NB4 control cells versus NB4 cells treated with SAHA (Vorinostat)
For a long time, the BARD1 (BRCA1-associated RING domain 1) protein has been considered as a BRCA1 (BReast Cancer susceptibility gene 1, early onset) interactor, and tumor suppressor mutated in breast and ovarian cancers. Despite its functions in a stable heterodimer with BRCA1, there is increasing ...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-37374 | biostudies-arrayexpress
GenomicsGenome-wide binding of GFI1 in NB4 cells
Genome-wide binding of GFI1 in NB4 cells
PRJNA643696 | ENA
TranscriptomicsA PU.1 suppressive target gene, metallothionein-1G, inhibits retinoic acid-induced NB4 cell differentiation
We recently revealed that myeloid master regulator PU.1 directly represses metallothionein (MT)-1G through its epigenetic activity, but the functions of MT-1G in myeloid differentiation remain unknown. To clarify this, we established MT-1G-overexpressing acute promyelocytic leukemia NB4 (NB4MTOE) ce...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-56739 | biostudies-arrayexpress
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