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TranscriptomicsGene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells
Treatment of acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA) results in terminal differentiation of leukemic cells toward neutrophil granulocytes. Administration of ATRA leads to massive changes in gene expression, including down-regulation of cell proliferation-related genes ...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress
TranscriptomicsNB4 cell line treatment with WEB-2170
This study reports the ability of WEB-2170, an antagonist of platelet-activating-factor receptor, to induce apoptosis in human acute myelogenous leukemia (AML) cells. Action mechanisms of WEB-2170 were first investigated in promyelocytic NB4 cells by DNA microarray profiling followed by morphologic...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-12645 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing analysis of NB4 cells overexpressing miR-125b
To better understand the mechanisms of blockage of myeloid differentiation and apoptosis and induction of proliferation by miR-125b, we proceeded to identify miR-125b target genes involved in these pathways. We analyzed the total cellular gene expression pattern by RNA-sequencing of the parental NB4...
ORGANISM(S): Homo sapiens 
2012-04-06 | E-GEOD-37061 | biostudies-arrayexpress
GenomicsChIPseq for NB4 cell line with either no treatment or LDB1 overexpression
ChIPseq for NB4 cell line with either no treatment or LDB1 overexpression
PRJNA881997 | ENA
GenomicsCUT-TAG for NB4 cell line with either IgG or LDB1 antibody
CUT-TAG for NB4 cell line with either IgG or LDB1 antibody
PRJNA947227 | ENA
GenomicsChIPseq for NB4 cell line in either the absence or presence of GNE987
ChIPseq for NB4 cell line in either the absence or presence of GNE987
PRJNA780172 | ENA
GenomicsCUT-TAG for NB4 cell line with either no treatment or LDB1 overexpression
CUT-TAG for NB4 cell line with either no treatment or LDB1 overexpression
PRJNA948392 | ENA
TranscriptomicsTranscription profiling of human ATRA treated NB4 cells
NB4 is an APL derived cell line, carrying the t(15;17) translocation and expressing the PML/RARa fusion protein. Still, an important question that remains to be addressed is whether PML/RARa target genes are transcriptionally suppressed in primary APL cells and re-activated in all-trans retinoic aci...
ORGANISM(S): Homo sapiens 
2009-12-14 | E-GEOD-19201 | biostudies-arrayexpress
GenomicsRNA-seq for NB4 cell line in either the absence or presence of CEBPG
RNA-seq for NB4 cell line in either the absence or presence of CEBPG
PRJNA738363 | ENA
GenomicsRNA-seq for NB4 cell line in either the absence or presence of LDB1
RNA-seq for NB4 cell line in either the absence or presence of LDB1
PRJNA883163 | ENA
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