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TranscriptomicsTranscriptional and post-transcriptional regulation of VEGF by the unfolded protein response
Inadequate extracellular conditions can adversely affect the environment of the ER and impinge on the maturation of nascent proteins. The resultant accumulation of unfolded proteins activates a signal transduction pathway, known as the unfolded protein response, which serves primarily to protect th...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-21979 | biostudies-arrayexpress
TranscriptomicsThe Mi-2 homolog, Mit1, actively positions nucleosomes within heterochromatic domains to suppress transcription
Nucleosome positioning is both active and passive and regulates access to the genome for replication, transcription and repair. Here we report that Mit1, a subunit of the fission yeast SHREC complex similar to Mi-2/NuRD, regulates transcription at regions of heterochromatin by positioning nucleosome...
ORGANISM(S): Schizosaccharomyces pombe 
2014-04-08 | E-GEOD-46649 | biostudies-arrayexpress
TranscriptomicsGene exrpression profiling of childhood adrenocortical tumors
Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermin...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75415 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells
The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress
UnknownHepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies.
Not available
S-EPMC8488877 | biostudies-literature
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