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TranscriptomicsArginine utilization following mycobacteria infection in macrophages is dependent on autocrine-paracrine signaling
Nitric oxide (NO) produced by macrophages (MØs) is toxic to both host tissues and invading pathogens and its regulation is therefore essential to suppress host cytotoxicity. MØ arginase 1 (Arg1) inhibits NO production by competing with NO synthases for arginine, the common substrate of NO synthases ...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-22935 | biostudies-arrayexpress
UnknownIdentification of Clinical and Biologic Correlates Associated With Outcome in Children With Adrenocortical Tumors Without Germline TP53 Mutations: A St Jude Adrenocortical Tumor Registry and Children's Oncology Group Study.
Not available
S-EPMC5721229 | biostudies-literature
TranscriptomicsGene expression profiles in mouse common myeloid progenitor (CMP) and leukemia cells expressing full-length MN1 or truncated versions of MN1 protein
We used Affymetrix microarrays to characterize gene expression profiles that were perturbed in common myeloid progenitor (CMP) cells due to enforced expression of full-length or truncated forms of MN1. Expression profiles of MN1-induced leukemias arising from whole bone marrow transduction were also...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-38767 | biostudies-arrayexpress
TranscriptomicsThe Mi-2 homolog, Mit1, actively positions nucleosomes within heterochromatic domains to suppress transcription
Nucleosome positioning is both active and passive and regulates access to the genome for replication, transcription and repair. Here we report that Mit1, a subunit of the fission yeast SHREC complex similar to Mi-2/NuRD, regulates transcription at regions of heterochromatin by positioning nucleosome...
ORGANISM(S): Schizosaccharomyces pombe 
2014-04-08 | E-GEOD-46649 | biostudies-arrayexpress
TranscriptomicsGermline genomic variations associated with childhood acute lymphoblastic leukemia
We identified germline single nucleotide polymorphisms (SNPs) associated with childhood acute lymphoblastic leukemia (ALL) and its subtypes. Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed (P<1x10-5) between a pediatric...
ORGANISM(S): Homo sapiens 
2009-08-16 | E-GEOD-17195 | biostudies-arrayexpress
TranscriptomicsRaptor/mTORC1-dependent metabolic programming of exit from quiescence underlies T cell activation and fate decisions
Naïve T cells respond to antigen stimulation by exiting from quiescence into clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that Raptor/mTORC1-dependent metabolic reprogramming is a central determinant of this transitional process. Loss of Rap...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51668 | biostudies-arrayexpress
TranscriptomicsVitamin A-deficient mice experience increased viral antigens and enhanced cytokine/chemokine production in nasal tissues following respiratory virus infection despite the presence of FoxP3+ T cells
Vitamin A deficiencies and insufficiencies affect hundreds of millions of people in both developing and developed countries. These individuals experience higher rates of mortality and increased morbidity during enteric and respiratory infections compared to those who are vitamin A sufficient. Previo...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-65805 | biostudies-arrayexpress
TranscriptomicsMolecular control of myeloid suppressors by death pathways
The goal of this study was to evaluate the mechanisms distinguishing the different forms of myeloid suppressors in cancer and inflammation, and their indivdual roles in T cell suppression We used microarrays to profile the expression profile of myeloid suppressor cells in mouse and human samples. Th...
ORGANISM(S): Homo sapiens 
2015-04-28 | E-GEOD-61479 | biostudies-arrayexpress
TranscriptomicsRegulation of tumor associated macrophages by cooperative inflammatory signaling
Tumor associated macrophages show signs of both, classical pro-inflammatory as well as alternative macrophage activation. The aim of this study was to compare TAMs across tumor types, to characterize their phenotype in detail and to identify the signaling nodules involved regulating classical and al...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-59047 | biostudies-arrayexpress
TranscriptomicsMito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...
ORGANISM(S): Mus musculus 
2015-04-21 | E-GEOD-57761 | biostudies-arrayexpress
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