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ATAC-Seq of WT and Nedd4L-cKO Muscle stem cells
RNA-seq of Muscle stem cells (WT and Nedd4L-cKO) and Myoblasts (WT)
Effect of depletion of NEDD4L on gene expression in EC9706 esophageal squamous cell carcinoma cells
Muscle stem cell quiescence is a complex and dynamic state. In this study we examined the role of the Ubiquitin Protease System in muscle stem cell function and quiescence. Using a genetic mouse model where Nedd4L is selectively deleted in myogenic cells, we characterized the effect of the loss of N...
ORGANISM(S): Mus musculus 
2024-05-06 | GSE230620 | GEO
NEDD4L plays a dual role in cancer. In order to verify its role in esophageal squamous cell carcinoma and the impact of NEDD4L deletion on different signaling pathways and gene expression, we used siRNA to transfect EC9706 cells to explore the role of NEDD4L deletion in esophageal squamous cell carc...
ORGANISM(S): Homo sapiens 
2024-11-27 | GSE252141 | GEO
Muscle stem cell quiescence is a complex and dynamic state. In this study we examined the role of the Ubiquitin Protease System in muscle stem cell function and quiescence. Using a genetic mouse model where Nedd4L is selectively deleted in myogenic cells, we characterized the effect of the loss of N...
ORGANISM(S): Mus musculus 
2024-05-06 | GSE230621 | GEO
NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis
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