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TranscriptomicsEctodysplasin regulates the lymphotoxin-beta pathway for hair differentiation
To find developmental stage specific genes controled by EDA Keywords: development or differentiation design,genetic modification design Triplicated for all samples
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-6952 | biostudies-arrayexpress
TranscriptomicsGenes regulated by T cell and B cell derived TNF in naive lymph nodes
We present a RNA microarray analysis of RNA`s extracted from naive mesenterial lymph nodes of mice with specific inactivation of tumor necrosis factor only in B cells (B-TNf mice) or in T- and B-cells (TB-TNF mice). Several genes are cooperatively regulated by T cell derived and B cell derived TNF ...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-8610 | biostudies-arrayexpress
UnknownIntrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity.
TNF is a multifunctional cytokine involved in autoimmune disease pathogenesis that exerts its effects through two distinct TNF receptors, TNFR1 and TNFR2. While TNF- and TNFR1-deficient (but not TNFR2-deficient) mice show very similar phenotypes, the significance of TNFR2 signaling in health and dis...
S-EPMC6304938 | biostudies-literature
UnknownCell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source.
Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti-TNF therapy. TNF is produced by a variety of cell types, and it can play either a beneficial or a deleterious role. In particular, in autoimmunity pathogenic TNF may be deri...
S-EPMC4801281 | biostudies-literature
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