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GenomicsEpigenetic changes due to histone eviction induced by anthracycline doxorubicin and aclarubicin
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33633 | biostudies-arrayexpress
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33624 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone eviction by FAIRE-Seq
A major class of chemotherapeutics targets topoisomerase II for DNA double-strand breaks and cancer cell elimination. We compare four members of this class?the anthracyclines doxorubicin, daunorubicin and aclarubicin that does not induce DNA breaks?and a different compound, etoposide. We define a no...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33632 | biostudies-arrayexpress
TranscriptomicsTissue selective effects of topoisomerase II inhibitors in vivo
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. In vitro experiments showed that doxorubicin can induce histone eviction as well as DNA damage, while etoposide can only induce DNA damage. Here, we compare the tran...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33626 | biostudies-arrayexpress
UnknownRNF26 binds perinuclear Vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress
Not available
S-SCDT-10_15252-EMBJ_2022111252 | biostudies-other
UnknownSKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport
Not available
S-SCDT-EMBOJ-2019-102301 | biostudies-other
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