Cases with Type 1 Diabetes (T1D) in the UK, were part of the Wellcome Trust Case Control Consortium (WTCCC) - http://www.wtccc.org.uk - that first reported in 2007:
Wellcome Trust Case Control Consortium (2007) Genome-wide association s...
Whole genome sequencing was performed with DNA extracted from fresh-frozen
tumor and normal material. Short insert DNA libraries were prepared with the TruSeq
DNA PCRfree sample preparation kit (Illumina) for paired-end sequencing at a
minimum read length of 2x100bp. Human DNA libraries were sequenc...
RNA-sequencing (RNA-seq) was performed with RNA extracted from fresh-frozen
human tumor tissue samples. cDNA libraries were prepared from poly-A selected
RNA applying the Illumina TruSeq protocol for mRNA. The libraries were then
sequenced with a 2 x 100bp paired-end protocol to a minimum mean cover...
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. We found bi-allelic inactivation of TP53 and RB1 in nearly all the tumors analyzed, sometimes by complex genomic rearrangements. Two tumors with wild-type RB1 had evidence of chromothripsis leadi...