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UnknownCep85 Relays Plk1 Activity to Phosphorylated Nek2A for Its Timely Activation in Centrosome Disjunction.
Not available
S-EPMC6317306 | biostudies-literature
UnknownNek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
Not available
S-EPMC10944510 | biostudies-literature
UnknownCharacterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.
Not available
S-EPMC4582193 | biostudies-literature
UnknownA unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Not available
S-EPMC7271329 | biostudies-literature
ProteomicsU2OS Nek2 KO global proteomics analysis
Nek2A is a cell cycle regulated kinase, which is involved in several cellular processes and overexpressed in numerous cancer types. It has been associated with chromosome instability, increased cell proliferation and drug resistance in cancers. With this analysis global proteomics levels of Nek2KO c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-28 | PXD046115 | Pride
Nek2a kinase Cancer 
UnknownComponents of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.
Not available
S-EPMC3939356 | biostudies-literature
TranscriptomicsBreast Brain Metastasis, Non-Neoplastic Brain, and Non-Neoplastic Breast Gene Expression
The central nervous system (CNS) is a common site of metastatic disease in patients with breast cancer and has few therapeutic options with dismal outcomes. The purpose of our study was to identify common and rare events that underlie breast cancer CNS metastasis. We performed deep genomic profiling...
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-52604 | biostudies-arrayexpress
UnknownNek2 kinase displaces distal appendages from the mother centriole prior to mitosis.
Not available
S-EPMC7055001 | biostudies-literature
ProteomicsThe Greatwall kinase safeguards the genome integrity by balancing the kinome activity in mitosis.
Mastl is commonly overexpressed in cancer, appearing as an alternative therapeutic anticancer target. Loss of Mastl induces multiple chromosomal mitotic errors that lead to the accumulation of micronuclei and multilobulated cells with polyploidy. Our detailed analyses display that loss of Mastl quic...
ORGANISM(S): Mus Musculus (mouse) 
2020-10-15 | PXD019297 | JPOST Repository
UnknownA unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase.
Not available
S-SCDT-EMBOR-2019-49831V1 | biostudies-other
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