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TranscriptomicsRNA-seq of human ex vivo ovarian cancer models - part III
Ascites or solid tumour samples from patients with ovarian cancer were collected and grown in culture as ex vivo models of purified tumour cells. RNA-seq was performed on these models to establish gene expression profiles, which allow identification of genes that are differentially expressed between...
ORGANISM(S): Homo sapiens 
2021-10-10 | E-MTAB-11000 | biostudies-arrayexpress
GenomicsA Genome-Wide Association Study of Heroin Dependence

This collaboration of Australian and American investigators aims to identify genes associated with liability for heroin dependence. The project uses a case-control design in which cases met lifetime DSM-IV criteria for heroin dependence. Controls included assessed individuals who did not meet DSM...

phs000277.v1.p1 | EGA
TranscriptomicsSingle cell RNA-seq of a human ex vivo ovarian model with matched stromal cells
single cell RNA-seq was performed on tumour and stromal cells from a single patient with ovarian cancer to establish gene expression profile differences between the two cell types and also heterogeneity within the tumour population.
ORGANISM(S): Homo sapiens 
2020-01-16 | E-MTAB-7249 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq from 10X for a living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
We validated fifteen models from “living biobank” to provide models that support interrogation of Chromosome Instability and to evaluate novel therapeutics. Single cell RNA-seq was performed on tumour and stromal cells from 4 patients with ovarian cancer to establish gene expression profile differe...
ORGANISM(S): Homo sapiens 
2020-01-23 | E-MTAB-8559 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
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