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MetabolomicsMonounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to ...
2014-06-17 | MTBLS92 | MetaboLights
TranscriptomicsGenome profile of human rectal tumors and response to neoadjuvant chemoradiotherapy
Background: Neoadjuvant chemoradiotherapy (NCRT) is the treatment of choice in advanced rectal cancer, even though there are many patients who will not benefit from it. There are still no effective methods for predicting which patients will respond or not. The present study aimed to define the genom...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-25885 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human squamous cell carcinomas to predict response to neoadjuvant chemoradiotherapy in oesophageal cancer patients
To use gene expression profiles to predict response to neoadjuvant chemoradiotherapy in oesophageal cancer patients.
ORGANISM(S): Homo sapiens 
2008-02-08 | E-MEXP-426 | biostudies-arrayexpress
TranscriptomicsMiRNA expression arrays from esophageal squamous cell carcinomas with different neoadjuvant chemoradiotherapy response
Preoperative chemoradiotherapy (CRT) followed by surgery has been proved to improve esophageal squamous cell carcinoma (ESCC) patients’ survival in comparison with surgery alone. However, the outcomes of CRT are heterogeneous, and no clinical or pathological method could predict CRT response. We ai...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-59974 | biostudies-arrayexpress
TranscriptomicsA specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer
Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-29298 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rectal adenocarcinomas biopsied before and after pre-operative short-course radiotherapy or 5-flurouracil-based chemoradiotherapy
The molecular mechanisms of clinical response or resistance to therapy were evaluated in colorectal cancer patients in a prospective biomarker discovery project. Rectal adenocarcinomas, biopsied before (diagnostic biopsy) and after (surgical resection) pre-operative short-course radiotherapy [RT] or...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-MEXP-1901 | biostudies-arrayexpress
TranscriptomicsOverall aiEMT in non-cancerous samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32700 | biostudies-arrayexpress
TranscriptomicsOverall aiEMT in surgical samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-33103 | biostudies-arrayexpress
TranscriptomicsIndividual aiEMT in surgical samples of esophageal cancer patients
Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling f...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-GEOD-32701 | biostudies-arrayexpress
TranscriptomicsNovel linkages between DCE-MRI and genomic profiling in locally advanced and inflammatory breast cancer
Gene expression signatures have the capacity to identify clinically significant features of breast cancer and can predict which individual patients are likely to be resistant to neoadjuvant therapy, thus providing the opportunity to guide treatment decisions. Data used in publication: Clin Cancer Re...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52322 | biostudies-arrayexpress
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