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MetabolomicsMonounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to ...
2014-06-17 | MTBLS92 | MetaboLights
MetabolomicsApplication of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Not available
ORGANISM(S): Homo sapiens 
ST002235 | MetabolomicsWorkbench
TranscriptomicsSerial gene expression analysis in locally advanced breast cancer patients who failed to respond to neoadjuvant chemotherapy
To elucidate candidate genes and pathways associated with poor response, we retrospectively analyzed gene expression profiles in serial biopsies from women with locally advanced breast cancer who failed to respond to anthracycline-based chemo followed by taxane in the I-SPY Of the 221 patients who c...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-32603 | biostudies-arrayexpress
TranscriptomicsDiscovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcom...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25055 | biostudies-arrayexpress
TranscriptomicsSERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer
Abstract Introduction Response rates to chemotherapy remain highly variable in breast cancer patients. We set out to identify genes associated with chemotherapy resistance. We analyzed what is currently the largest single-institute set of gene expression profiles derived from breast cancers prior t...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-34138 | biostudies-arrayexpress
TranscriptomicsRadiation induced gene signature predicts pathologic complete response to neoadjuvant chemotherapy in breast cancer patients
Purpose:The identification of biomarkers predictive of neoadjuvant chemotherapy response in breast cancer patients would be an important advancement in personalized cancer therapy. We hypothesized that due to similarities between radiation and chemotherapy induced cellular response mechanisms, radia...
ORGANISM(S): Mus musculus 
2015-01-21 | E-GEOD-48073 | biostudies-arrayexpress
TranscriptomicsNovel linkages between DCE-MRI and genomic profiling in locally advanced and inflammatory breast cancer
Gene expression signatures have the capacity to identify clinically significant features of breast cancer and can predict which individual patients are likely to be resistant to neoadjuvant therapy, thus providing the opportunity to guide treatment decisions. Data used in publication: Clin Cancer Re...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52322 | biostudies-arrayexpress
TranscriptomicsGenomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
This SuperSeries is composed of the following subset Series: GSE25055: Discovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer GSE25065: Validation cohort for genomic predictor of response and survival following neoadju...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25066 | biostudies-arrayexpress
TranscriptomicsNeoadjuvant chemotherapy modulates T cell responses in high-grade serous ovarian cancer metastases
Our data suggest that neoadjuvant chemotherapy enhances anti-cancer responses of T cells in peritoneal metastases of patients with high-grade serous ovarian cancer but does not decrease levels of immune checkpoint molecules, providing a rationale for sequential chemo-immunotherapy. tRNA was isolated...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-71340 | biostudies-arrayexpress
TranscriptomicsValidation cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcom...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25065 | biostudies-arrayexpress
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