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MetabolomicsMetabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling
Untargeted metabolomics has the potential to improve the predictivity of in vitro toxicity models and therefore may aid the reduction of expensive and laborious animal models. Here we describe a chronic nephrotoxicity study conducted on a human renal proximal tubular epithelial cell line (RPTEC/TERT...
2015-09-07 | MTBLS140 | MetaboLights
ModelsRenal Transport
A workspace to manage a collection of models relating to the renal nephron and the kidney.
nephron | Physiome Model Repository
TranscriptomicsIntrinsic age-dependent changes and cell-cell contacts regulate nephron progenitor lifespan
Purpose: To use single-cell RNA-Seq analysis of nephron progenitors in order to determine transcrptional differences as nephron progenitors age. Methods: Using a combination of FACS sorting and a Fluidigm Single-cell auto-prep system, we generated high-throughput RNA-SEQ data of nephron progenitors ...
ORGANISM(S): Mus musculus 
2015-12-23 | E-GEOD-66202 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in nephron progenitors lacking miR-17~92
Purpose: The goal of this study is to compare the differential expression of transcripts in control kidneys compared to kidneys lacking the miR-17~92 cluster in nephron progenitors and their derivatives by RNA-seq to identify potential miRNA targets in the mutant kidneys. mRNA profiles of control an...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-52514 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Six2-positive nephron progenitors from mouse embryo
Nephron progenitors in the embryonic kidney propagate while generating differentiated nephrons. However, the progenitors in mice terminally differentiate shortly after birth. We defined culture conditions to selectively propagated nephron progenitors in vitro in an undifferentiated state. To underst...
ORGANISM(S): Mus musculus 
2016-04-14 | E-GEOD-79024 | biostudies-arrayexpress
Transcriptomicsp53 Enables Self Renewal of Nephron Progenitor Cells
p53 limits the self-renewing ability of a variety of stem cells. Here, contrary to its classical role in restraining cell proliferation, we demonstrate a divergent function of p53 in maintenance of self-renewal of the nephron progenitor population in the embryonic mouse kidney. p53-null nephron prog...
ORGANISM(S): Mus musculus 
2015-02-16 | E-GEOD-56253 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse nephron to assess circadian rhythms
Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechani...
ORGANISM(S): Mus musculus 
2009-10-30 | E-GEOD-17739 | biostudies-arrayexpress
GenomicsChIP-seq of Smad3 and EZH2 binding sites in hiPSC and iPSC-derived Nephron Progenitors
Chromatin immunoprecipitation sequencing analysis of Smad3 and EZH2 binding sites in hIPSCs and iPSC-derived nephron progenitors.
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-10910 | biostudies-arrayexpress
GenomicsGenome-wide maps of Six2 and b-catenin in mesenchymal nephron progenitors
Self-renewing undifferentiated nephron progenitors express Six2, a transcription factor that is required for their maintenance as undifferentiated progenitors. Differentiation of nephron progenitors is triggered by Wnt/b-catenin signaling. In order to understand how Six2 and Wnt signaling counteract...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-39837 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat metanephric mesenchyme induced to convert into nephron epithelia
During kidney development segmented epithelia of the nephron derive from progenitor cells in the metanephric mesenchyme after induction by secreted molecules from the ureteric bud. We have identified three distinct inductive activities from a ureteric bud cell line. These include leukemia inhibitory...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5478 | biostudies-arrayexpress
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