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TranscriptomicsDrosophila melanogaster Show a Threshold Effect in Response to Radiation
We investigate the biological effects of radiation using Drosophila Melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no ...
ORGANISM(S): Drosophila melanogaster 
2016-06-12 | E-GEOD-47999 | biostudies-arrayexpress
TranscriptomicsDrosophila melanogaster transcriptional profiling over life span: Indy vs. Controls
Transcriptional profiling of Indy long lived flies and controls over the course of their entire lifespan. Mutations in the Indy gene extend life span in Drosophila melanogaster. This study investigates the changes in gene expression over time in Indy206 flies heterozygous over Canton-S (Indy206/CS)...
ORGANISM(S): Drosophila melanogaster 
2010-05-22 | E-GEOD-13872 | biostudies-arrayexpress
TranscriptomicsDietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster.
Dietary restriction (DR) is one of the most studied interventions known to extend life span. The robustness of its effect across species suggests the existence of conserved mechanisms to reduce mortality rates and increase longevity. However, because DR elicits a large number of physiological change...
ORGANISM(S): Drosophila melanogaster 
2014-06-01 | E-GEOD-47631 | biostudies-arrayexpress
TranscriptomicsReduced Expression of the Proto-oncogene Myc Increases Mouse Longevity and Enhances Healthspan
MYC is a pleiotropic transcription factor that regulates numerous pathways and whose deregulation promotes cancer. Myc+/- mice have extended lifespan relative to their wild type littermates. To better understand the effects of the Myc+/- genotype on cellular processes, microarrays were performed on ...
ORGANISM(S): Mus musculus 
2014-02-22 | E-GEOD-55272 | biostudies-arrayexpress
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