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ProteomicsCharacterization of novel a-Mangostin and Paeonol derivatives with cancer-selective cytotoxicity
a-Mangostin and Paeonol have shown anti-cancer and anti-inflammatory properties, however these two natural compounds have no clinical value because of their low solubility and low membrane permeability. In this study, we screened chemically synthesized derivatives from these two natural compounds as...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024999 | Pride
Colorectal cancer  anti-cancer drugs  cancer-selective compounds  natural compound derivatives  colon cancer organoids  paeonol  a-mangostin 
GenomicsSingle base resolution analysis of 5-formyl and 5-carboxyl cytosine reveals the actual promoter DNA methylation dynamics in embryonic stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-55660 | biostudies-arrayexpress
GenomicsIdentification of Myc and Max genomic targets in mouse embryonic stem cells.
Myc is a master transcription factor that has been demonstrated to be required for embryonic stem cell (ESC) pluripotency, self-renewal, and inhibition of differentiation. Although recent works identified several Myc-targets in ESC the list of Myc binding sites is largely incomplete due to the low s...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-48175 | biostudies-arrayexpress
UnknownTranscriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome.
Not available
S-EPMC4999837 | biostudies-literature
GenomicsTranscriptional regulation of Tet1 during development
5-hydroxymethylcytosine (5hmC) is a recently discovered epigenetic modification that is lost in human cancers. Formation of 5hmC is catalysed by the Ten eleven translocation (TET) proteins that mediate the sequential oxidation of 5-methylcytosine (5mC) to 5hmC, leading to eventual DNA demethylation....
ORGANISM(S): Mus musculus 
2015-08-04 | E-GEOD-57250 | biostudies-arrayexpress
TranscriptomicsRole of miRNAs in acute kidney injury recovery induced by mesenchymal stromal cells and derived extracellular vesicles.
Phenotypic changes induced by extracellular vesicles (EVs) have been implicated in the recovery of acute kidney injury (AKI) induced by mesenchymal stromal cells (MSCs). miRNAs are potential candidates for cell reprogramming towards a pro-regenerative phenotype. The aim of the present study was to e...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-59958 | biostudies-arrayexpress
UnknownFunctional outcomes after transanal total mesorectal excision (TaTME): a random forest analysis to predict patients' outcomes.
Not available
S-EPMC9985820 | biostudies-literature
TranscriptomicsRetinoic acid induces Snai1 in stem cells of the preimplantation blastocyst to initiate differentiation
Although much is known about the pluripotency self-renewal circuitry, the molecular events that lead embryonic stem cells (ESCs) exit from pluripotency and begin differentiation are largely unknown. We found that the zinc finger transcription factor Snai1, involved in gastrulation and epithelial- me...
ORGANISM(S): Mus musculus 
2015-01-12 | E-GEOD-57854 | biostudies-arrayexpress
UnknownTRAPPC9-related autosomal recessive intellectual disability: report of a new mutation and clinical phenotype.
Not available
S-EPMC3548258 | biostudies-literature
TranscriptomicsIntegrated genomics approach to detect allelic imbalances in multiple myeloma, SNP data
A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide dosage effect on gene and microRNA expression Multiple myeloma (MM) is characterized by marked genomic instability. Beyond structural rearrangements, a relevant...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-16121 | biostudies-arrayexpress
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