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UnknownPhysiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study.

Purpose

Frailty, a phenotype reported among 9.9% of individuals 65 years old and older (9.6% of women; 5.2% of men), has not been assessed among adult childhood cancer survivors (CCS). We estimated the prevalence of frailty and examined associations with morbidity and mortality.

Methods

S-EPMC3871511 | biostudies-literature
UnknownAge-dependent changes in health status in the Childhood Cancer Survivor cohort.

Purpose

To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort.

Methods

Adult survivors of childhood cancer and siblings, all participants of the Childhood Cancer Survivor Study, completed three surveys assessing health status. At each ...
S-EPMC4314595 | biostudies-literature
UnknownIndividual prediction of heart failure among childhood cancer survivors.

Purpose

To create clinically useful models that incorporate readily available demographic and cancer treatment characteristics to predict individual risk of heart failure among 5-year survivors of childhood cancer.

Patients and methods

Survivors in the Childhood Cancer Survivor Study ...
S-EPMC4314592 | biostudies-literature
UnknownIdentification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent funct...
S-EPMC3709460 | biostudies-literature
UnknownEpigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we com...
S-EPMC3848248 | biostudies-literature
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