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TranscriptomicsRNA-seq of SUPT1, LOUCY, JURKAT and DND41 after treatment with 5-azacytidine and Vitamin C
TET2 is a know tumorsuppressor gene involved in the demethylation of DNA. TET2 catalyses the conversion of 5-methyl cytosine (5-mC) to 5-hydroximethyl cytosine (5-hmC), an important step in the removal of methylation from the DNA. In T-All mutations in TET2 are rare, however we have found that it is...
ORGANISM(S): Homo sapiens 
2021-08-04 | E-MTAB-10512 | biostudies-arrayexpress
TranscriptomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
Comparison of the methylation profile of mouse embryonic fibroblasts (MEFs) before and during adaptation to cell culture conditions. Matched expression data is deposited under accession: E-MTAB-3172
ORGANISM(S): Mus musculus 
2014-12-17 | E-MTAB-3176 | biostudies-arrayexpress
TranscriptomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
5-hmC profiling of mouse embryonic fibroblasts before and during adaptation to cell culture conditions using hMeDIP-chip
ORGANISM(S): Mus musculus 
2014-12-17 | E-MTAB-3177 | biostudies-arrayexpress
TranscriptomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
Gene expression in mouse embryonic fibroblasts (MEFS) during adaptation to cell culture conditions was analysed, and revealed rapid reprogramming of the transcription in culture.
ORGANISM(S): Mus musculus 
2014-12-17 | E-MTAB-3172 | biostudies-arrayexpress
GenomicsRapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems (hmeDIP-seq)
5hmC profiling of mouse embryonic fibroblasts before and during adaptation to cell culture conditions using 5hmC-Seq. Related data sets for this study have also been deposited in ArrayExpress under accessions E-MTAB-3172 (expression profiling by microarray), E-MTAB-3176 (methylation profiling of 5-m...
ORGANISM(S): Mus musculus 
2014-12-19 | E-MTAB-3183 | biostudies-arrayexpress
GenomicsLow pass whole methylome enzymatic sequencing of four AML cell lines untreated and after treatment with different concentrations of 5-azacytidine (AZA), 5-aza-2′-deoxycytidine (DEC), Cytarabine (ARAC) and GSK3685032 (GSK5032) for 3 and 7 days
We conducted low-coverage whole-genome enzymatic methylation sequencing (EM-seq) on four commercially available AML cell lines to assess their global DNA methylation profiles following treatment with varying concentrations (0–3000 nM) of three different hypomethylating agents—5-azacytidine (AZA), 5-...
ORGANISM(S): Homo sapiens 
2025-04-10 | E-MTAB-14969 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Changes in Allergic Patients Correlate with Symptom Severity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-50387 | biostudies-arrayexpress
TranscriptomicsDNA methylation analysis in infants with low and high body fatness
We combined genome-wide DNA methylation profiling of buccal cells from 47 full-term one-week old infants with accurate measurements of infant fat mass and fat-free mass using air-displacement plethysmography and found no significant a between DNA methylation and infant body composition
ORGANISM(S): Homo sapiens 
2020-11-11 | E-MTAB-9596 | biostudies-arrayexpress
TranscriptomicsHydroxymethyl DNA-IP of genomic DNA for many different normal human tissues
5-hmC is a novel epigenetic mark derived from oxidation of methylcytosine. We profile this mark in several normal human tissues 5-hmC patterns are highly tissue specific and enriched in the body of transcribed genes 5-hmC patterns are highly tissue specific and enriched in the body of transcribed ge...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-33219 | biostudies-arrayexpress
TranscriptomicsAllergen challenged CD4+ cells from allergic patients and healthy controls
Gene expression (Npatients = 21, Ncontrols = 21) of CD4+ T-cells failed to seperate patients with seasonal allergic rhinitis (SAR) and healthy controls in an in vitro model system in which purified PBMCs from patients and healthy controls were challenged with allergen for 7 days. PBMCs from 21 patie...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50223 | biostudies-arrayexpress
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