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TranscriptomicsTranscription profiling by array of wild type and Pcsk5 Vcc mutant mouse embryos
We have identified an ENU-induced recessive mouse mutation (Vcc) with a pleiotropic phenotype overlapping including cardiac, tracheo-esophageal, anorectal, axial skeletal antero-posterior patterning defects, limb malformations, presacral mass, renal and palatal agenesis, and pulmonary hypoplasia. It...
ORGANISM(S): Mus musculus 
2008-06-27 | E-TABM-443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from individuals with airway hyperactivity and goblet cell metaplasia post-Sendai virus infection
Mice representing phenotypic extremes of airway hyperreactivity and goblet cell metaplasia post-Sendai virus infection were identified from a 500 mouse F2 cohort (CB6F2/J). Whole lung RNA from 3 mice at each extreme was analyzed via microarray for gene expression. Subsequent pairwise comparisons b...
ORGANISM(S): Mus musculus 
2007-07-06 | E-GEOD-3925 | biostudies-arrayexpress
TranscriptomicsGlycerol metabolism and PrfA activity in Listeria monocytogenes
Listeria monocytogenes is able to efficiently utilize glycerol as carbon source. In a defined minimal medium the growth rate is similar (during balanced growth) in presence of glycerol as in presence of glucose or cellobiose. Comparative transcriptome analyses of L. monocytogenes showed in the prese...
ORGANISM(S): Listeria monocytogenes 
2008-05-30 | E-GEOD-11459 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of E14.5 Foxd1 null and wild type kidneys
Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development and its inactivation results in failure of nephron progenitor cell differentiation. Foxd1 is expressed in interstitial cells adjacent to ne...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52354 | biostudies-arrayexpress
TranscriptomicsNative functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
Spinobulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by expansion of a polyglutamine tract in the androgen receptor (AR). This mutation confers toxic function to AR through unknown mechanisms. Mutant AR toxicity requires binding of its hormone ligand, suggesting that pathogenesi...
ORGANISM(S): Drosophila melanogaster 
2010-09-23 | E-GEOD-23802 | biostudies-arrayexpress
TranscriptomicsCharacterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
To identify genes expressed during initiation of lung organogenesis, we generated transcriptional profiles of the prospective lung region of the mouse foregut (mid-foregut) microdissected from embryos at three developmental stages between embryonic day 8.5 (E8.5) and E9.5. This period spans from lun...
ORGANISM(S): Mus musculus 
2010-01-14 | E-GEOD-19873 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsAlteration of microRNA gene expression by EBV encoded LMP1 oncogene
The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10105 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of the two major subtypes of diffuse large B cell lymphoma
The goal of this study is to identify the transcriptome differences between the two major subtypes of diffuse large B cell lymphoma (DLBCL). DLBCL is the most common form of non-Hodgkin’s lymphoma and has two major subtypes: germinal center B-cell-like (GCB) and activated B-cell-like (ABC). When c...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-50721 | biostudies-arrayexpress
TranscriptomicsIntegrating phenotypic and expression profiles to map arsenic response networks
The parent S. cerevisiae strain, BY4741, and specific gene deletions of the parent S.cerevisiae strain BY4741 were treated with 100uM NaAsO2 (AsIII) for 2h and compared to the untreated counterpart (yap1Î? vs. yap1Î? 2h 100uM AsIII, cad1Î? vs. cad1Î? 2h 100uMAsIII, rpn4Î? vs. rpn4Î? 2h 100uM AsIII, ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-05 | E-GEOD-1798 | biostudies-arrayexpress
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