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MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsThe Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is ...

2021-12-03 | MTBLS2288 | MetaboLights
TranscriptomicsSingle-cell RNA-Seq of bovine macrophage cell lines from two cow strains infected with Theileria
To understand the immune response of cows to the apicomplexan parasite Theileria annulata, we used ex vivo isolate cells derived from two infected calve : Holstein 12886 (Bos taurus), which is known to be susceptible to the disease, and Sahiwal 82H (Bos indicus), which is known to be resistant. The ...
ORGANISM(S): Bos taurus 
2024-10-09 | E-MTAB-14450 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - 10x data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. RNA-seq was done usin...
ORGANISM(S): Homo sapiens 
2018-10-02 | E-MTAB-6701 | biostudies-arrayexpress
TranscriptomicsExpression and Splicing Analysis of Myotonic Dystrophy and Other Dystrophic Muscle
The prevailing patho-mechanistic paradigm for myotonic dystrophy (DM) is that the aberrant presence of embryonic isoforms is responsible for many, if not most, aspects of the pleiotropic disease phenotype. In order to identify such aberrantly expressed isoforms in skeletal muscle of DM type 1 (DM1)...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-48828 | biostudies-arrayexpress
UnknownEvaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes.
Not available
S-EPMC4798642 | biostudies-literature
UnknownGene family information facilitates variant interpretation and identification of disease-associated genes in neurodevelopmental disorders.
Not available
S-EPMC7079346 | biostudies-literature
UnknownBlocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma
Not available
S-SCDT-10_15252-EMMM_202115200 | biostudies-other
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