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TranscriptomicsRNA-seq of nonstenotic and stenotic areas of patients with Crohn’s disease
Fibrostenotic disease is a common complication in Crohn’s disease (CD). We performed bulk RNA sequencing (n=16) of paired intestinal biopsies taken from nonstenotic and stenotic areas of patients with CD (n=8).
ORGANISM(S): Homo sapiens 
2023-04-26 | E-MTAB-12788 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of long-term stimulated primary murine intestinal fibroblasts with interleukin-36.
Previous stimulation experiments of stimulated primary murine colonic fibroblasts with IL-36R ligands for 4h in vitro showed an upregulation of pro-inflammatory cytokines e.g. IL-6, IL-1b and chemokines e.g. CXCL1, CCL2 indicating an important role for IL-36 in inflammation. We were interested in an...
ORGANISM(S): Mus musculus 
2018-11-19 | E-MTAB-6476 | biostudies-arrayexpress
TranscriptomicsIL-36R stimulation of colonic mouse fibroblasts
Intestinal fibroblasts from the colons of C57BL/6 wild-type mice were grown in the presence or absence of IL-36ÉŁ (30 ng/ml) for 4 hours. The experimental setup included 6 samples from 3 colons in a pairwise design (3 stimulated vs 3 unstimulated). Profiling of whole-genome transcriptomic patterns w...
ORGANISM(S): Mus musculus 
2015-12-31 | E-MTAB-3814 | biostudies-arrayexpress
TranscriptomicsExpression data from colon epithelium of STAT3IEC-KO in acute DSS colitis
STAT3 is a pleiotropic transcription factor with important functions in cytokine signalling in a variety of tissues. However, the role of STAT3 in the intestinal epithelium is not well understood. Here we demonstrate that development of colonic inflammation is associated with the induction of STAT3...
ORGANISM(S): Mus musculus 
2009-05-08 | E-GEOD-15955 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of fibroblast subpopulations (COLVI+ vs. COLVI-) in mice
Functional studies using genetically modified mice with COLVI-specific STAT3 loss- or gain-of function demonstrated a critical role of STAT3 activation through IL-6 and IL-11 in fibroblasts during colorectal tumorigenesis in vivo. To reveal molecular mechanism specifically involved the STAT3 driven ...
ORGANISM(S): Mus musculus 
2020-01-27 | E-MTAB-7764 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of colitis-associated and sporadic colorectal tumors in mice
To uncover molecular mechanisms specifically involved in the pathogenesis of colitis-associated colon cancer (CAC), we studied tumorigenesis in experimental models of CAC and sporadic CRC that mimic characteristics of human CRC. Using comparative whole genome expression profiling, we observed differ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43338 | biostudies-arrayexpress
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
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