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MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Feces metabolomics)

Maternal folic acid intake is crucial for the development of the offspring's nervous system, and folic acid metabolism disorders during pregnancy lead to neural tube defects (NTDs) in the fetus. Folic acid and vitamins biosynthesis is a major biochemical feature of gut microbiota. The complex and...

2022-12-05 | MTBLS4893 | MetaboLights
MetabolomicsIntergenerational Association of Gut Microbiota and Metabolism with Perinatal Folate Metabolism and Neural Tube Defects (Brain tissue metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-12-05 | MTBLS4894 | MetaboLights
TranscriptomicsAnalysis of conditional loss of Geminin in neural tube and paraxial tissues at E10.5 by laser capture microdissection
To better understand the role of Geminin during germ layer specification, we bred floxed Geminin mice to Mox2-Cre mice. Mutants (fl/fl; cre/o) had spinal neural tube defects with complete penetrance. We obtained neural tube and paraxial tissue by laser capture microdissection and analyzed total RNA...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-42052 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse embryo during neural tube closure
This data series was used for two separate studies. The initial study was aimed to idenify expression changes brought about by the Cecr2Gt45Bic mutation during neural closure. The study included two different strains, BALB/cCrl in which Cecr2GT45Bic shows a neural tube defect phenotype and FVB/N in ...
ORGANISM(S): Mus musculus 
2012-02-27 | E-GEOD-30957 | biostudies-arrayexpress
TranscriptomicsConcerted involvement of Cdx/Hox genes and Wnt signalling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogous 13 genes also induces vertebral axis truncat...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30113 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetuses using oligonucleotide microarray analysis of fetal mRNA isolated from amniocytes to investigate the genetic background of the polygenic neural tube defect Spina bifida
In polygenic disorders we do not know exactly, how many genes are involved in the pathomechanism, but the analysis of fetal gene expression can get us closer to the solution. In our study we were searching for the genetic background of the polygenic neural tube defect, which is the second most commo...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-4182 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the developing neural tube
At an incidence of approximately 1/1000 births, neural tube defects (NTDs) comprise one of the most common and devastating congenital disorders. In an attempt to enhance and expand our understanding of neural tube closure, we undertook a high-throughput gene expression analysis of the neural tube as...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-39442 | biostudies-arrayexpress
TranscriptomicsMethylation Patterns in Han Chinese Neural Tube Defects Pedigrees
In this study, in 3 Han Chinese NTD pedigrees (2 with multiple affected children), with no information on folic acid deficiency or supplement, we examined genome-wide methylation profiles of each individual in these families.
ORGANISM(S): Homo sapiens 
2016-12-15 | E-MTAB-5320 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling at neural tube closure site
Maternal diabetes is a teratogen that can lead to neural tube closure defects in the offspring. We therefore sought to compare gene expression profiles at the site of neural tube closure between stage-matched embryos from normal dams, and embryos from diabetic dams. Neurulation-stage mouse embryos a...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-41876 | biostudies-arrayexpress
TranscriptomicsDEVELOPMENTAL MicroRNA EXPRESSION PROFILING OF MURINE NEURAL TUBE
BACKGROUND: Development of the neural tube is a highly orchestrated process relying on precise, spatio-temporal expression of numerous genes as well as hierarchies of signal transduction and gene regulatory networks. Disruption of expression of a number of genes participating in these networks is be...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-20879 | biostudies-arrayexpress
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