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MetabolomicsRepurposing statins and phenothiazines to treat chemoresistant neuroblastoma

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurpos...

2025-11-13 | MTBLS13246 | MetaboLights
MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
MetabolomicsReduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance
Not available
ORGANISM(S): Homo sapiens 
ST002054 | MetabolomicsWorkbench
TranscriptomicsNeuroblastoma Disease Pathogenesis is Modulated By Epigenetically Regulated MicroRNAs - Gene expression data
The data represents gene expression data from 42 primary neuroblastoma tumors using Affymetrix exon arrays. Data on an accompanying MeDIP experiment on tiling arrays is also available from ArrayExpress (see E-MEXP-3498).
ORGANISM(S): Homo sapiens 
2012-10-16 | E-MEXP-3517 | biostudies-arrayexpress
TranscriptomicsMicroarray Quality Control Study 2, Neuroblastoma one-color
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-179 | biostudies-arrayexpress
TranscriptomicsCaSR modulator in neuroblastoma model [human]
CaSR modulation inhibits neuroblastoma growth 8 control and 7 samples treated with CaSR allosteric activator
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-73504 | biostudies-arrayexpress
TranscriptomicsCaSR modulator in neuroblastoma model [mouse]
CaSR modulation inhibits neuroblastoma growth 8 control and 8 samples treated with CaSR allosteric activator
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-73506 | biostudies-arrayexpress
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