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MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
MetabolomicsRepurposing statins and phenothiazines to treat chemoresistant neuroblastoma

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurpos...

2025-11-13 | MTBLS13246 | MetaboLights
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
MetabolomicsReduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance
Not available
ORGANISM(S): Homo sapiens 
ST002054 | MetabolomicsWorkbench
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-18 | MSV000083590 | MassIVE
TranscriptomicsNeuroblastoma Disease Pathogenesis is Modulated By Epigenetically Regulated MicroRNAs - Gene expression data
The data represents gene expression data from 42 primary neuroblastoma tumors using Affymetrix exon arrays. Data on an accompanying MeDIP experiment on tiling arrays is also available from ArrayExpress (see E-MEXP-3498).
ORGANISM(S): Homo sapiens 
2012-10-16 | E-MEXP-3517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells identifies molecular effectors of unconjugated bilirubin
This SuperSeries is composed of the following subset Series:; GSE16656: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblatoma SH-SY5Y cells: 24h; GSE16766: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neurobl...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16768 | biostudies-arrayexpress
TranscriptomicsCaSR modulator in neuroblastoma model [human]
CaSR modulation inhibits neuroblastoma growth 8 control and 7 samples treated with CaSR allosteric activator
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-73504 | biostudies-arrayexpress
TranscriptomicsCaSR modulator in neuroblastoma model [mouse]
CaSR modulation inhibits neuroblastoma growth 8 control and 8 samples treated with CaSR allosteric activator
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-73506 | biostudies-arrayexpress
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