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MetabolomicsGut Microbiota Mediates Maternal PM2.5 Exposure-induced Neurodevelopmental Disorder in offspring via Disturbing the Glutamate Metabolism: Evidence from Multiomics Analysis

While accumulating evidence links maternal PM2.5 exposure to offspring neurodevelopmental impairments, yet the underlying biological pathways require further elucidation. To address this, female ICR mice are exposed to filtered air (FA) or concentrated ambient particulate matter (CAP) for three ...

2026-01-05 | MTBLS13599 | MetaboLights
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
MetabolomicsElevated lysophosphatidylcholines during SSRI-induced neural differentiation correlate with early neurodevelopmental symptoms

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
ProteomicsAutoinhibition of Trio guanine nucleotide exchange factor activity for Rac1 by its spectrin repeats is disrupted by neurodevelopmental disorder-related genetic variants
Crosslinking MS of SR6-GEF1 construct of Human Trio. BS3 crosslinking of wild-type and three point mutants implicated in neurodevelopmental disorders (E883D, R1078Q, D1368V). Data acquired using FAIMS ion mobility source with each sample acquired at 4 different CVs (-40, -50, -60, -70V).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089621 | MassIVE
MetabolomicsAlterations in gut microbiota composition, plasma lipids, and brain activity, suggest inter-connected pathways influencing malnutrition-associated cognitive and neurodevelopmental changes.

Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions, with nearly half of child deaths under five linked to malnutrition. Survivors face lasting consequences, including impaired neurocognitive development, leading to cognitive and behavioura...

2024-11-27 | MTBLS10066 | MetaboLights
TranscriptomicsEpigenome analysis of control and neurodevelopmental disorder lymphoblastoid cell lines
Genome wide DNA methylation profiling of control and neurodevelopmental disorder lymphoblastoid cell lines (LCL). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in LCLs. Samples included 19 control, 18 Rett s...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-34099 | biostudies-arrayexpress
TranscriptomicsArray-CGH in a boy with an occurrence of neurodevelopmental disorders and epilepsy
This analysis includes the whole-genome screening of unbalanced chromosomal rearrangements (copy-number variants; CNV) in a boy with neurodevelopmental disorders and epilepsy.
ORGANISM(S): Homo sapiens 
2020-01-31 | E-MTAB-8147 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human differentiated vs. undifferentiated SH-SY5Y cells transfected with a MeCP2 (transcriptional repressor) decoy to investigate the neurodevelopmental disorder Rett syndrome
Rett syndrome (RTT) is an X-linked dominant neurodevelopmental disorder caused by mutations in MECP2, encoding methyl-CpG-binding protein 2. MeCP2 is a transcriptional repressor elevated in mature neurons and is predicted to be required for neuronal maturation by regulating multiple target genes. Id...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4600 | biostudies-arrayexpress
GenomicsNeurodevelopmental disorder genes
Neurodevelopmental disorder genes
PRJNA1451859 | ENA
GenomicsGenome sequencing coupled with iPSC technology identifies GTDC1 as a novel candidate gene involved in Neurodevelopmental Disorders
We identified genomic structural alterations of six patients with signs of neurodevelopmental disorder (NDDs) that harbour chromosomal rearrangements using large-insert paired-end tag sequencing (DNA-PET). This technique allowed the refinement of chromosomal breakpoints and lead to the identificatio...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-51430 | biostudies-arrayexpress
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