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ProteomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma
Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. How...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD063342 | Pride
Metabolic diversity De novo pyrimidine synthesis Neurofibromin 2 (nf2) Pleural mesothelioma (pm) Synthetic lethality 
UnknownLipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Not available
S-EPMC5889391 | biostudies-literature
TranscriptomicsMicroarray Analysis in Vestibular Schwannomas
Vestibular Schwannomas are benign neoplasms that arise from the vestibular nerve. The hallmark of these tumors is the biallelic inactivation of NF2. Transcriptomic alterations, such as the Nrg1/ErbB2 pathway, have been described in Schwannomas. Here, we have performed a whole transcriptomic analysis...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-39645 | biostudies-arrayexpress
UnknownA deletion causing NF2 exon 9 skipping is associated with familial autosomal dominant intramedullary ependymoma.
Not available
S-EPMC3895380 | biostudies-literature
UnknownNeurofibromin 2 modulates Mammalian Ste2-like kinases1/2 and large tumor suppressor gene1 expression in A549 lung cancer cell line.
Not available
S-EPMC11236635 | biostudies-literature
UnknownNeurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis.
Not available
S-EPMC7828193 | biostudies-literature
UnknownNonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2).
Not available
S-EPMC6858664 | biostudies-literature
TranscriptomicsNf2 orchestrates β-arrestin2-biased PTH1R signaling to safeguard skeletal integrity
Precise spatiotemporal regulation of parathyroid hormone (PTH) and PTH-related peptide (PTHrP) signaling through the PTH1R is fundamental to skeletal development and metabolic bone remodeling, yet the intracellular mechanisms that fine-tune this signaling remain a central unanswered question. Here, ...
ORGANISM(S): Mus musculus 
2026-06-01 | GSE319151 | GEO
UnknownA novel NF2 splicing mutant causes neurofibromatosis type 2 via liquid-liquid phase separation with large tumor suppressor and Hippo pathway.
Not available
S-EPMC9589172 | biostudies-literature
GenomicsNf2 orchestrates β-arrestin2-biased PTH1R signaling to safeguard skeletal integrity
Nf2 orchestrates β-arrestin2-biased PTH1R signaling to safeguard skeletal integrity
PRJNA1422208 | ENA
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