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ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
UnknownBrain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Not available
S-EPMC6405777 | biostudies-literature
UnknownNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes.
Not available
S-EPMC9468065 | biostudies-literature
UnknownNeuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease.
Not available
S-EPMC5988730 | biostudies-literature
UnknownInteraction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models.
Not available
S-EPMC8224073 | biostudies-literature
UnknownNorepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus.
Not available
S-EPMC5014224 | biostudies-literature
GenomicsImpact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
Impact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
PRJNA1327429 | ENA
OtherImpact of Alzheimer’s disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections widely across the brain to regulate multiple functions including sleep, memory, arousal, and cognition. The LC has several unique cellular features including the presence of neuromelanin (NM) and its ...
ORGANISM(S): Homo sapiens 
2026-02-16 | GSE307866 | GEO
UnknownImpact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus.
Not available
S-EPMC12636595 | biostudies-literature
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