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Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
RNA-seq of NEAT1 knockdown in neuronal excitability
We investigated the role of NEAT1 knockdown on neuronal excitability in iPSC-derived neurons.
ORGANISM(S): Homo sapiens 
MicroRNA regulates protein expression of cells by repressing translation of specific target messenger transcripts. Loss of the neuron specific microRNA miR-128 in Dopamine D1-receptor expressing neurons in the murine striatum (D1-MSNs) lead to increased neuronal excitability, locomotor hyperactivity...
ORGANISM(S): Mus musculus 
Severe deficiency of voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
Glioblastoma cells imitate neuronal excitability in humans
Small cell lung cancer induces synaptic scaling to alter neuronal excitability
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically ...
ORGANISM(S): Mus Musculus 
2023-02-09 | PXD038454 |
7q11.23 CNV alters ribosomal biogenesis, mTOR and neuronal intrinsic excitability [ribosome footprinting]
7q11.23 CNV alters ribosomal biogenesis, mTOR and neuronal intrinsic excitability [RNA-seq]
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