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MetabolomicsSIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a ...
2024-04-01 | MTBLS8439 | MetaboLights
ModelsOuzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis
Ouzounoglou2014 - Modeling of alpha-synuclein effects on neuronal homeostasis This model is described in the article: In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis. Ouzounoglou E, Kalamatianos D, Emmanouilidou E, Xi...
2024-09-02 | BIOMD0000000559 | BioModels
TranscriptomicsFoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis expression profile between six independant neural stem cell lines (three FoxO null and three wild type) were compared
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-18308 | biostudies-arrayexpress
ModelsProctor2011_ProteinHomeostasis_NormalCondition
This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE2011; 6(7): e22038. doi:10.1371/journal.pone.0022038, Abstract: Neurodegeneration is a...
2024-09-02 | BIOMD0000000344 | BioModels
MetabolomicsBifidobacterium animalis subsp. lactis BD1 restores neurotransmitter homeostasis in chronically stressed mice via tryptophan metabolic reprogramming

Background: Chronic psychological stress is a major precipitating factor for neuropsychiatric disorders, yet the underlying mechanisms remain incompletely understood. The gut-brain axis has emerged as a critical regulator of mood and behavior, but how specific commensal microbes modulate host neu...

2025-10-23 | MTBLS13208 | MetaboLights
GenomicsMitochondrial Fission Factor (MFF) regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
Mitochondrial Fission Factor (MFF) regulates mitochondrial Ca2+ homeostasis and neuronal activity in AgRP neurons
PRJNA1429310 | ENA
GenomicsGTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
PRJNA663319 | ENA
TranscriptomicsGlobal transcriptomic profiling of nitric oxide-mediated neuronal death
Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive o...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-22087 | biostudies-arrayexpress
TranscriptomicsRegulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis
The current study has investigated the hypothalamic gene expressions regulated by glucocorticoid (GC), key hormones in energy homeostasis. Using serial analysis of gene expression (SAGE) method, we have studied the effects of adrenalectomy (ADX) and GC on the transcriptomes of mouse hypothalamus. Ap...
ORGANISM(S): Mus musculus 
2006-09-22 | E-GEOD-3366 | biostudies-arrayexpress
TranscriptomicsPurification of neuronal precursors from the adult mouse brain: a comprehensive gene expression analysis
The progeny of neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain consists in polysialylated NCAM-expressing immature neurons (PSA(+) cells), which migrate to the olfactory bulb (OB) to differentiate into GABAergic interneurons. We purified murine PSA(+) cells directly f...
ORGANISM(S): Mus musculus 
2007-09-21 | E-GEOD-9081 | biostudies-arrayexpress
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