Neuronal inhibition

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Unknown (6187)
Transcriptomics (875)
Genomics (683)
Proteomics (159)
Other (27)
Metabolomics (27)
Models (5)
Methylation profiling (2)
Clinical (1)
Multiomics (1)

Organisms

Mus musculus (580)
Homo sapiens (411)
Rattus norvegicus (75)
Arabidopsis thaliana (19)
Drosophila melanogaster (16)
Colinus virginianus (15)
Saccharomyces cerevisiae (12)
Caenorhabditis elegans (11)
Danio rerio (9)
Gallus gallus (4)
Rattus rattus (4)
Sus scrofa (4)
Pan troglodytes (4)
synthetic construct (4)
Macaca mulatta (3)
Schizosaccharomyces pombe (2)
Oryza sativa Japonica Group (2)
Triticum aestivum (2)
Apis mellifera (2)
Bos taurus (2)
Canis lupus familiaris (2)
Rattus (1)
Manihot esculenta (1)
Mus musculus musculus (1)
Pectobacterium polaris (1)
Trypanosoma brucei brucei (1)
Zea mays (1)
Aedes aegypti (1)
Plasmodium falciparum (1)
Escherichia coli (1)

Organisms

Mus musculus (260)
Homo sapiens (155)
Rattus norvegicus (21)
Colinus virginianus (7)
Danio rerio (6)
Caenorhabditis elegans (5)
Drosophila melanogaster (5)
Sus scrofa (3)
Xenopus laevis (2)
Xenopus tropicalis (2)
Gallus gallus (2)
Hemicentrotus pulcherrimus (1)
Lytechinus variegatus (1)
Taeniopygia guttata (1)
Apis mellifera (1)
Canis lupus familiaris (1)
Felis catus (1)
Macaca mulatta (1)

Repository

biostudies-arrayexpress (570)
ENA (538)
geo (462)
pride (100)
MassIVE (34)
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EGA (16)
iProX (11)
jPOST (6)
BioModels (5)
PAXDB (5)
PanoramaPublic (3)
GPMDB (1)

Tissue

Brain (47)
Cell culture (28)
Neuron (5)
Permanent cell line cell (4)
Astrocyte (2)
Cerebral cortex neuron (2)
Cerebrospinal fluid (2)
Dopaminergic neuron (2)
Microglial cell (2)
Muscle (2)
Neuron of cerebral cortex (2)
Neuron of the forebrain (2)
Neuronal stem cell (2)
Stem cell (2)
Whole body (2)
Adipose tissue (1)
Blood (1)
Blood plasma (1)
Brain cortex cell line (1)
Brain microvascular endothelial cell (1)
CCD-18Co cell (1)
Cerebral cortex pyramidal neuron (1)
Cerebrospinal fluid secreting cell (1)
Connective tissue (1)
Cortex (1)
Electrically active cell (1)
Embryonic stem cell (1)
Epithelial cell (1)
Primary cerebral cortical neuronï¿½ (1)
Schwann cell (1)

Disease

Alzheimer's disease (6)
Normal (2)
Neuroblastoma (2)
Brain cancer (2)
Mouse neuroblastoma (1)
Pneumococcal meningitis (1)
Colorectal Neoplasms (1)
Not Available (1)
Amyotrophic lateral sclerosis (1)
Disease free (1)
Fibrosarcoma (1)
Human immunodeficiency virus infectious disease (1)
Huntington Disease (1)
Hydrocephalus (1)
Kidney disease (1)
Merkel cell carcinoma (1)
Neurotrophic keratoconjunctivitis (1)
Ovarian cancer (1)
Parkinson's disease (1)
Progressive supranuclear palsy (1)
Skin cancer (1)
Synucleinopathy (1)
Traumatic brain injury (1)

Technology Type

Mass Spectrometry (100)
Shotgun proteomics (49)
Bottom-up proteomics (21)
Mass spectrometry (15)
Data-dependent acquisition (14)
Data-independent acquisition (14)
Mass spectrometry assay (12)
Affinity purification coupled with mass spectrometry proteomics (12)
Gel-based experiment (7)
SWATH MS (6)
Top-down proteomics (3)
Illumina HiSeq 2000 (2)
Affinity proteomics (2)
DiaPASEF (2)
ILLUMINA, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina HiSeq 2500 (1)
ILLUMINA, NextSeq 500 (1)
Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500, ILLUMINA, Illumina HiSeq 2000 (1)
All-ion fragmentation (1)

Instrument Platform

Illumina NovaSeq 6000 (27)
NextSeq 500 (14)
Illumina HiSeq 2000 (10)
Illumina HiSeq 4000 (9)
Illumina HiSeq 2500 (8)
NextSeq 2000 (6)
Illumina Genome Analyzer IIx (3)
Illumina MiSeq (3)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
Sony SH800 (2)
Affymetrix GeneChip Scanner 3000 7G (2)
Axon- GenePix4000B (2)
NextSeq 550 (2)
Illumina NOVAseq 6000 (1)
Python (1)
Nugen Ovation SPIA; Wafergen’s Apollo liquid handler; KAPA Hyper Prep Library Kit (1)
QIAGEN TissueLyser II (1)
Isoflurane euthanasia chamber (1)
Chromium Next GEM Chip G (1)
10X v3 (1)
STAR (1)
Single Cell/Low Input RNA Library Prep Kit for Illumina (#E6420S, New England Biolabs) (1)
RNA Micro Kit (Qiagen). (1)
Dr. Tom Multi-omics Data Mining System (1)
Animal Experiment Facility (1)
SPF Animal Room (1)
PCR Thermocycler, Fragment Analyzer (1)
Centrifuge, Nucleic Acid Quantification Instrument (1)
Biosafety Cabinet, Liquid Nitrogen Tank, -80°C Freezer (1)
Single cells were captured using the 10x Genomics Chromium Controller. (1)

Publication Date

2026 (171)
2025 (123)
2024 (84)
2013 (77)
2015 (70)
2014 (69)
2022 (62)
2016 (60)
2011 (60)
2023 (57)
2012 (50)
2008 (46)
2009 (45)
2010 (44)
2020 (43)
2021 (38)
2018 (32)
2019 (28)
2017 (27)
2007 (16)
2006 (10)
2005 (2)
2004 (2)
2002 (1)

UNIPROT ID/AC

10116.ENSRNOP00000000015 (3)
10116.ENSRNOP00000004657 (3)
10116.ENSRNOP00000012904 (3)
10116.ENSRNOP00000013100 (3)
10116.ENSRNOP00000018309 (3)
10116.ENSRNOP00000038798 (3)
10116.ENSRNOP00000050143 (3)
10116.ENSRNOP00000050794 (3)
10116.ENSRNOP00000059474 (3)
10116.ENSRNOP00000061523 (3)
10116.ENSRNOP00000065069 (3)
10116.ENSRNOP00000067294 (3)
10116.ENSRNOP00000067711 (3)
1433B_RAT (3)
1433E_RAT (3)
1433F_RAT (3)
1433G_RAT (3)
1433T_RAT (3)
1433Z_RAT (3)
2ABA_RAT (3)
2ABD_RAT (3)
3HIDH_RAT (3)
5NT3B_RAT (3)
6PGL_RAT (3)
A0A096MIV5_RAT (3)
A0A096MIV6_RAT (3)
A0A096MIX2_RAT (3)
O43526 (1)
O88944 (1)
P29992 (1)

CHEBI ID

CHEBI:15422 (6)
CHEBI:15741 (5)
CHEBI:16761 (5)
CHEBI:16919 (5)
CHEBI:17154 (5)
CHEBI:17568 (5)
CHEBI:17822 (5)
CHEBI:26271 (5)
CHEBI:28300 (5)
CHEBI:14314 (4)
CHEBI:15698 (4)
CHEBI:16027 (4)
CHEBI:16031 (4)
CHEBI:16449 (4)
CHEBI:16704 (4)
CHEBI:17368 (4)
CHEBI:17596 (4)
CHEBI:15996 (1)
CHEBI:16595 (1)
CHEBI:16749 (1)
CHEBI:17526 (1)
CHEBI:17552 (1)
CHEBI:18348 (1)
CHEBI:18420 (1)
CHEBI:25107 (1)
CHEBI:30111 (1)
CHEBI:38309 (1)
CHEBI:38322 (1)
CHEBI:43000 (1)
CHEBI:5235 (1)

Metabolite Name

Creatine (12)
Inosine (12)
Uridine (11)
Adenosine (10)
Choline (10)
Pantothenic acid (10)
Sarcosine (10)
Uric acid (10)
Glycerophosphocholine (9)
Guanosine (9)
Histidine (9)
Hypoxanthine (9)
Alanine (8)
Allantoin (8)
Citrulline (8)
Creatinine (8)
Deoxycholic acid (8)
Glyceric acid (8)
L-Arginine (8)
Methionine (8)
NAD (8)
Oleamide (8)
Oleic acid (8)
Proline (8)
Purine (8)
Pyroglutamic acid (8)
Succinic acid (8)
Urocanic acid (8)
3-phosphoglycerate (7)
4-Pyridoxic acid (7)

First Public Date

2026 (120)
2025 (113)
2024 (56)
2023 (56)
2014 (45)
2022 (40)
2020 (25)
2019 (23)
2018 (17)
2021 (15)
2017 (14)
2015 (6)
2016 (4)
2013 (4)

Modelling Approach

Ordinary differential equation model (4)
Physiologically based pharmacokinetic model (1)

Study status

Recruiting (1)

Lab affiliation

Key Laboratory of Brain Functional Genomics of Shanghai and Ministry of Education, Institute of Brain Functional Genomics, School of Life Science and the Collaborative Innovation Center for Brain Science, East China Normal University, Shanghai, China (3)
Technion Faculty of Medicine and Network Biology Research Laboratories, (3)
Department of Neurology, Yale School of Medicine, Yale University, new haven CT, USA (2)
1Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA (1)
Associate Professor, Department of Cell and Systems Biology Director, Human Biology Program University of Toronto, Canada (1)
Baylor College of Medicine Houston, Texas (1)
CECAD and Institute for Genetics Joseph-Stelzmann Straße 26 University of Cologne, Cologne, Germany (1)
Center for Basic Research, Biomedical Research Foundation Academy of Athens, Soranou Efesiou 4, Athens 11527 (1)
Center for Neuroscience and Cell Biology of theUniversity of Coimbra (1)
Chemical Biology & Proteomics, Biogen (1)
Children's Hospital of Philadelphia 416B Abramson Pediatric Research Center Philadelphia, PA 19104 Office: 215-590-5320 Lab: 215-590-5319 (1)
Core Facility for Mass Spectrometry and Proteomics, Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany (1)
DZNE Munich Neuroproteomics Feodor-Lynen-Str. 17 81377 München Germany (1)
Department for Cell Biology Biomedical Center (BMC) Medical Faculty, LMU Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany (1)
Department of Biochemistry and Molecular Biology University of Southern Denmark Campusvej 55 DK-5230 Odense M Denmark (1)
Department of Biomedical Sciences, University of Copenhagen, Denmark (1)
Department of Chemistry The Scripps Research Institute (1)
Department of Chemistry and Biochemistry, the University of Maryland, College Park, MD, 20742, USA (1)
Department of Chemistry, Yale University (1)
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, 88100, Italy (1)
Department of Experimental and Clinical Medicine, University of Catanzaro,Catanzaro (IT) (1)
Department of Neurology and Neuroscience Yale University (1)
Department of Neurology, Faculty of Medicine, University of Cologne and University Hospital Cologne, Kerpener Strasse 62, 50937 Cologne, Germany (1)
Department of Neuroscience , Tufts University (1)
Department of Neuroscience, Tufts University School of Medicine (1)
Department of Neuroscience, University of Florida (1)
Department of Neurosurgery and Institute for NeurosciencesUniversity Hospital of Toulouse, Toulouse, France. Toulouse NeuroImaging Center (ToNIC), University of Toulouse, INSERM, UPS, Toulouse, France. (1)
Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, and 2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA (1)
Department of Pathology, University of Cambridge (1)
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. (1)

IsPrivate

False (5)

Modification

2x(15)N labeled L-lysine (1)
4-tetrahydrothiazine-3-carboxylic acid (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (345)
RNA-seq of coding RNA (89)
ChIP-seq (47)
Methylation profiling by high throughput sequencing (11)
RNA-seq of coding RNA from single cells (8)
Other (7)
RNA-seq of non coding RNA (7)
ChIP-chip by tiling array (6)
Unknown experiment type (5)
Methylation profiling by array (5)
RNA-seq of total RNA (5)
Transcription profiling by SAGE (3)
Transcription profiling by tiling array (3)
RNAi profiling by array (3)
ATAC-seq (3)
Cell line - High-throughput sequencing (2)
RIP-seq (2)
Single nucleus RNA sequencing (2)
DNA-seq (2)
GRO-seq (1)
Baseline (1)
Two-color microarray (1)
Human - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
ChIP-chip by array (1)
Genotyping by array (1)
CLIP-seq (1)
Spatial transcriptomics by high-throughput sequencing (1)
Bisulfite-seq (1)

Release Date

2025 (613)
2022 (593)
2021 (569)
2023 (553)
2020 (511)
2024 (476)
2018 (391)
2017 (379)
2019 (378)
2016 (353)
2015 (308)
2014 (277)
2013 (232)
2012 (188)
2011 (181)
2010 (163)
2009 (134)
2008 (119)
2026 (114)
2007 (73)
2006 (41)
2004 (28)
2005 (25)
2003 (16)
2002 (10)
2001 (7)
2000 (7)
1999 (6)
1998 (4)
1997 (4)

Location

Italy (1)

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Neuronal Hyperactivity due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer’s Disease-like Pathology

Metabolite profiling was performed on metabolites extracted from the entorhinal cortex and primary visual cortex of 14-15 month old APOE3/3, APOE3/4 and APOE4/4 mice. Metabolites were run on a TOF Mass Spectrometer using an ANP column. Initial analysis was done in an untargeted manner, and processin...

2017-09-05 | MTBLS530 | MetaboLights

Gut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Murine assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9100 | MetaboLights

Combined transcriptomic and metabolomic profiling identifies candidate pathways associated with adventitious root inhibition by watermelon scions in pumpkin rootstocks

Adventitious root (AR) formation is essential for grafted seedling propagation, yet its suppression in specific scion-rootstock combinations remains a significant challenge. To determine the mechanisms by which watermelon scions inhibit AR formation in pumpkin rootstocks, this study utilized a doubl...

2026-10-24 | MTBLS15154 | MetaboLights

Notch inhibition in microRNA-mediated neuronal reprogramming promotes neurite extension

PRJNA1061533 | ENA

Control of neuronal excitation-inhibition balance by BMP-SMAD1 signaling

PRJNA1075070 | ENA

Notch inhibition in microRNA-mediated neuronal reprogramming promotes neurite extension (PID21)

PRJNA1062362 | ENA

Control of neuronal excitation-inhibition balance by BMP-SMAD1 signaling [Smad1cKOvsctrl_RNAseq]

PRJNA1075451 | ENA

Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression]

Neurogenesis is a pro-survival process that comprises of dendritic and axonal growth, synaptogenesis, synaptic and neuronal pruning. These complex processes are determined by temporal gene expression during development, which is in turn tightly regulated by long non-coding RNAs and microRNAs. In thi...

ORGANISM(S): Mus musculus

2014-10-24 | E-GEOD-44833 | biostudies-arrayexpress

Control of neuronal excitation-inhibition balance by BMP-SMAD1 signaling [RNA-seq]

PRJNA1075449 | ENA

Control of neuronal excitation-inhibition balance by BMP-SMAD1 signaling [ChIP-seq]

PRJNA1075671 | ENA

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