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MetabolomicsNeuronal tRNA modifications in Aplysia californica are repatterned during behavioral habituation
Transfer RNA (tRNA) modifications have been increasingly implicated as post-transcriptional regulators of basic neuronal functions. However, characterizing tRNA modification profiles in specific neural circuits that control well-defined behaviors is notoriously difficult due to the complexity of con...
2026-09-01 | MTBLS15420 | MetaboLights
MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
ProteomicsMitochondrial Network Organization during Neuronal Reprogramming, MT_UDF_SEC
The study focuses on an extensive biochemical fractionation with in-depth quantitative mass spectrometric profiling in the mitochondrial (mt) extracts of cultured human NTera2 embryonal carcinoma stem cells (i.e. ECSCs or undifferentiated state) and upon exposure to retinoic acid-induced differentia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD009834 | Pride
Biochemical fractionation  ci and civ deficiencies  differentiated neuronal cells  human ntera2 embryonal carcinoma stem cells  mass spectrometry  mitochondrial proteins  mitochondrial interaction landscape  proteomics  protein complexes  patient fibroblasts  neurodegeneration  orphans 
ProteomicsMitochondrial Network Organization during Neuronal Reprogramming, MT_DF_SEC
The study focuses on an extensive biochemical fractionation with in-depth quantitative mass spectrometric profiling in the mitochondrial (mt) extracts of cultured human NTera2 embryonal carcinoma stem cells (i.e. ECSCs or undifferentiated state) and upon exposure to retinoic acid-induced differentia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD009833 | Pride
Biochemical fractionation  ci and civ deficiencies  differentiated neuronal cells  human ntera2 embryonal carcinoma stem cells  mass spectrometry  mitochondrial proteins  mitochondrial interaction landscape  proteomics  protein complexes  patient fibroblasts  neurodegeneration  orphans 
ProteomicsMitochondrial Network Organization during Neuronal Reprogramming, MT_UDF_WAX
The study focuses on an extensive biochemical fractionation with in-depth quantitative mass spectrometric profiling in the mitochondrial (mt) extracts of cultured human NTera2 embryonal carcinoma stem cells (i.e. ECSCs or undifferentiated state) and upon exposure to retinoic acid-induced differentia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD009832 | Pride
Biochemical fractionation  ci and civ deficiencies  differentiated neuronal cells  human ntera2 embryonal carcinoma stem cells  mass spectrometry  mitochondrial proteins  mitochondrial interaction landscape  proteomics  protein complexes  patient fibroblasts  neurodegeneration  orphans 
ProteomicsMitochondrial Network Organization during Neuronal Reprogramming, MT-DF-WAX
The study focuses on an extensive biochemical fractionation with in-depth quantitative mass spectrometric profiling in the mitochondrial (mt) extracts of cultured human NTera2 embryonal carcinoma stem cells (i.e. ECSCs or undifferentiated state) and upon exposure to retinoic acid-induced differentia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD009831 | Pride
Biochemical fractionation  ci and civ deficiencies  differentiated neuronal cells  human ntera2 embryonal carcinoma stem cells  mass spectrometry  mitochondrial proteins  mitochondrial interaction landscape  proteomics  protein complexes  patient fibroblasts  neurodegeneration  orphans 
GenomicsNeuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis
Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis
PRJNA1173233 | ENA
GenomicsInterleukin-4 receptor signaling modulates neuronal network activity
Interleukin-4 receptor signaling modulates neuronal network activity
PRJNA825260 | ENA
TranscriptomicsKMT2D haploinsufficiency in Kabuki Syndrome disrupts neuronal function through transcriptional and chromatin rewiring independent of H3K4-monomethylation
Kabuki Syndrome (KS) is a multisystemic rare disorder, characterized by growth delay, distinctive facial features, intellectual disability, and rarely autism spectrum disorder. This condition is mostly caused by de novo mutations of KMT2D, encoding a catalytic subunit of the COMPASS complex involved...
ORGANISM(S): Homo sapiens 
2022-12-25 | E-MTAB-10244 | biostudies-arrayexpress
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