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MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12482 | MetaboLights
MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12483 | MetaboLights
MetabolomicsGut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Murine assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9100 | MetaboLights
MetabolomicsGut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Human assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9087 | MetaboLights
TranscriptomicsMalignant Fibrous Histiocytoma - Pleomorphic Sarcoma, NOS -Gene expression, Histology and clinical course -A pilot study
This study was performed to identify gene expression differences in not otherwise specified soft tissue sarcomas (NOS, malignant fibrous histiocytomas) and correlate them to histological findings and the clinical course. RNA was isolated and differential gene expression was analysed by the microarra...
ORGANISM(S): Homo sapiens 
2011-01-03 | E-GEOD-14325 | biostudies-arrayexpress
TranscriptomicsMek inhibition, NOS inhibition, and nNOS knockout
embryonic cortical neuron treated with CSS, NMDA and NMDA with Mek inhibitor: replicate 1: GSM49556, GSM49557, GSM49558 replicate 2: GSM49559, GSM49560, GSM49561 nNOS KO brain cortex and wild-type littermate brain cortex: GSM49562, GSM49563 embryonic cortical neuron treated with CSS, NMDA and NMDA...
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2572 | biostudies-arrayexpress
ModelsChen2007_NeuronalEndothelialNOS
This a model from the article: Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Chen K, Popel AS Free Radic Biol Med. 2007 Mar 15;4...
2005-01-01 | MODEL0491251823 | BioModels
UnknownPulsed ENDOR determination of the arginine location in the ferrous-NO form of neuronal NOS.
Not available
S-EPMC3386476 | biostudies-literature
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs.
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44265 | biostudies-arrayexpress
UnknownNitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.
Not available
S-EPMC6730309 | biostudies-literature
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