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GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq]
Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq]
PRJNA1471016 | ENA
GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq]
Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq]
PRJNA1471026 | ENA
GenomicsHypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution
Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution
PRJNA1251611 | ENA
GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]
Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]
PRJNA1471023 | ENA
TranscriptomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq]
Brain aging is associated with neurovascular uncoupling, blood-brain barrier (BBB) dysfunction, neuroinflammation, and cognitive decline. Brain endothelial cells are essential for maintaining BBB integrity and neurovascular homeostasis and are enriched for the transcription factor Krüppel-like facto...
ORGANISM(S): Mus musculus 
2026-05-28 | GSE333394 | GEO
GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq]
Brain aging is associated with neurovascular uncoupling, blood-brain barrier (BBB) dysfunction, neuroinflammation, and cognitive decline. Brain endothelial cells are essential for maintaining BBB integrity and neurovascular homeostasis and are enriched for the transcription factor Krüppel-like facto...
ORGANISM(S): Mus musculus 
2026-05-28 | GSE333397 | GEO
GenomicsSingle-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus
Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus
PRJNA1321899 | ENA
TranscriptomicsHypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution
Arterial hypertension is a leading cause of cognitive impairment, attributed to hemodynamic insufficiency, blood-brain barrier disruption, and white matter damage. However, the molecular mechanisms by which hypertension affects brain cells remain unclear. Using scRNA-seq in a mouse model of hyperten...
ORGANISM(S): Mus musculus 
2025-04-17 | GSE294795 | GEO
GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq]
Omni-ATAC sequencing was performed on purified brain endothelial nuclei from young and aged endothelial-specific Klf4 knockout (EC-K4KO) and WT Cre mice to investigate chromatin accessibility changes associated with endothelial aging and neurovascular dysfunction. Endothelial KLF4 loss induced chrom...
ORGANISM(S): Mus musculus 
2026-05-28 | GSE333395 | GEO
UnknownAPOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.
Not available
S-EPMC4626092 | biostudies-literature
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