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GenomicsInhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles
Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles
PRJNA1070310 | ENA
UnknownSphingolipid metabolism and neutral sphingomyelinases.
Not available
S-EPMC4043343 | biostudies-literature
TranscriptomicsInhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles
Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin to produce ceramide-a lipid influencing membrane rigidity and essential for EV generation. This study explores the impact of inhibiting neutral SMase (...
ORGANISM(S): Homo sapiens 
2025-03-12 | GSE254401 | GEO
UnknownThematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases.
Not available
S-EPMC2311444 | biostudies-literature
UnknownMammalian neutral sphingomyelinases: regulation and roles in cell signaling responses.
Not available
S-EPMC3405913 | biostudies-literature
UnknownNeutral sphingomyelinases control extracellular vesicles budding from the plasma membrane.
Not available
S-EPMC5699186 | biostudies-literature
UnknownMolecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2).
Not available
S-EPMC10682184 | biostudies-literature
TranscriptomicsLoss of ER and nuclear envelope-associated neutral sphingomyelinase SMPD4 causes a severe neurodevelopmental disorder with microcephaly and congenital arthrogryposis
Several neurodevelopmental processes including neuronal survival, migration and differentiation are controlled by sphingolipid metabolism. Sphingomyelin is an abundant component of cell membranes. Sphingomyelinases generate ceramide from sphingomyelin as a second messenger in intracellular signaling...
ORGANISM(S): Homo sapiens 
2019-12-31 | GSE133264 | GEO
UnknownImpact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity.
Not available
S-EPMC10296953 | biostudies-literature
ProteomicsThe ceramide-dependent EV secretome differentially affects prostate cancer cell migration
Tumor-derived extracellular vesicles (EVs) play an important role in cancer pro-gression. Neutral Sphingomyelinases (nSMases) are lipid modifying enzymes that modu-late the secretion of EVs from cells. How nSMase activity and therefore ceramide genera-tion affects the composition and functionality o...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD062469 | Pride
Neutral sphingomyelinases Smpd2 Smpd3 Cell migration Extracellular matrix 
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