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MetabolomicsAn NMR metabolomics analysis pipeline for human neutrophil samples with limited source material
Untargeted 1H NMR metabolomics is a robust and reproducible approach to study metabolism in biological samples, providing unprecedented insight into altered cellular processes associated with human diseases. Metabolomics is increasingly used alongside other -omics techniques, such as proteomics and ...
2025-11-06 | MTBLS6220 | MetaboLights
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsA robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling
BACKGROUND: Neutrophils are phagocytic innate immune cells that play essential roles in host defence, but are also implicated in inflammatory diseases such as rheumatoid arthritis (RA) where they contribute to systemic inflammation and joint damage. Transcriptomic analysis of neutrophils has reveale...
2018-12-06 | MTBLS658 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
MetabolomicsNeutrophil metabolomics in COVID-19
Not available
ORGANISM(S): Homo sapiens 
ST002477 | MetabolomicsWorkbench
MetabolomicsFungus Rhizopus microsporus var. rhizopodiformis Promotes Hepatic Steatosis via Upregulation of Hepatic Neutrophil Degranulation

Objective:

Metabolic associated fatty liver disease (MAFLD) affects approximately 25% of the global population, posing a serious threat to public health, and its pathogenesis remains largely unknown. Gut fungi play a significant role in the development of liver diseases, but the gut microbi...

2025-12-01 | MTBLS13120 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-15 | MTBLS13694 | MetaboLights
MetabolomicsAlistipes putredinis Alleviates Metabolic-Associated Fatty Liver Disease via the Acetate-GPR43 Axis by Suppressing Neutrophil ROS Generation

Background & Aims:

Intestinal dysbiosis contributes to the pathogenesis of metabolic-associated fatty liver disease (MAFLD), though precise bacterial targets and mechanisms remain incompletely elucidated. This study investigated whether the depletion of Alistipes putredinis (AP) in adol...

2026-01-15 | MTBLS13691 | MetaboLights
MetabolomicsHistidine improves Hashimoto thyroiditis by inhibiting the production of Neutrophil Txtracellular Traps

Objective: Metabolite abnormalities are potentially implicated in pathogenesis of Hashimoto’s thyroiditis (HT). An in-depth study of the relationship between HT and small molecule metabolites, as well as its pathogenesis, can help enhance the diagnosis, prognosis, and treatment of HT patients.

2025-10-12 | MTBLS12333 | MetaboLights
MetabolomicsSpatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

Spatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

2025-11-26 | MTBLS12782 | MetaboLights
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