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ProteomicsSaliva peptidome correlates with oral cancer prognosis
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. In this wor...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020211 | Pride
Protease inhibitors Oral squamous cell carcinoma Proteolysis Peptidome Oral cancer 
ProteomicsSynthesis of guanylylated peptides derived from norovirus VPg as molecular tools for studying norovirus replication C4PR_LIV
Norovirus, a member of the Caliciviridae family, is a positive-sense single-stranded RNA (+ssRNA) virus and a leading cause of acute gastroenteritis worldwide, especially affecting young children and the elderly.​​ Due to a lack of specific treatment, norovirus infection causes 200,000 deaths each y...
ORGANISM(S): Murine Norovirus Mus Musculus 
PXD075074 | panorama
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1
We have previously shown that Thioredoxin-1 (Trx-1) binds to the cytoplasmic domain of ADAM17 (ADAM17cyto), A Disintegrin And Metalloprotease 17, and that the destabilization in their interface of interaction favors the Trx-1 dimeric and inactive state. These studies opened the question of whether A...
ORGANISM(S): Homo Sapiens 
2021-03-12 | PXD020016 | panorama
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