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MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
ProteomicsHDXMS comparison of NFkB (p50(39-350)/RelA(19-321) vs NFkB (p50(39-350)/RelA(19-549)
HDXMS comparison of NFkB (p50(39-350)/RelA(19-321) vs NFkB (p50(39-350)/RelA(19-549)
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-12 | MSV000089247 | MassIVE
TranscriptomicsTesting LPS induced gene expression in murine MEFs with different NFkB knockout
NFkB is a family of transcriptional factors that are responsible for inflammatory and immune gene expression. RelA, RelB and cRel are the transactivation domain containing family members. P50 encoded by Nfkb1 is the primary dimerization partner. Many NFkB deficient mice are embryonic lethal. In ord...
ORGANISM(S): Mus musculus 
2016-06-27 | E-MTAB-4412 | biostudies-arrayexpress
ProteomicsTargeting synergetic endothelial inflammation by inhibiting NFKB and JAK-STAT pathways
Multiple systemic vascular inflammatory disorders are associated with endothelial dysfunction and elevated levels of TNFα and IFNγ. Combined TNFα and IFNγ stimulation induces synergetic hyperinflammation in endothelial cells (ECs) through activation of the NFKB and JAK/STAT pathways. Here we assess ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD064921 | Pride
Proteomics Inflammation Inhibitors Endothelial cells 
TranscriptomicsNFkB perturbation followed by genome-wide allelic-expression data assessment
We developed a method that perturbs transcription factor followed by monitoring genome-wide allelic expression measurements in living cells. As a model for this novel approach, we chose the factor NFκB. We performed TNF-α induction coupled to inhibition of NFκB in LCLs followed by Allelic Express...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-61254 | biostudies-arrayexpress
UnknownNovel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB.
Not available
S-EPMC4147345 | biostudies-literature
TranscriptomicsGenetic and drug perturbation of components in the NFkB signaling pathway in 11-18 cells
Through the study of EGFR-mutant lung adenocarcinoma we show that NFkB signaling is rapidly engaged by EGFR oncogene inhibition to promote tumor cell persistence and therapy resistance. Unexpectedly, we found that EGFR oncogene inhibition induced an EGFR-TRAF2-RIP1-IKK complex that stimulated an NFk...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-65420 | biostudies-arrayexpress
UnknownNFkB Pathway and Hodgkin Lymphoma.
Not available
S-EPMC9495867 | biostudies-literature
ProteomicsSTING induces LUBAC synthesis of linear ubiquitin chains to activate NFkB
STING activation by cyclic dinucleotides in mammals induces Type I Interferon- and NFkB-related gene expression, and the lipidation of LC3B at Golgi membranes. While the mechanisms of the Interferon-related responses are well understood, the mechanism of NFkB activation mediated by STING activation,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092940 | MassIVE
TranscriptomicsA Proneural to Mesenchymal Transition Mediated by NFkB Promotes Radiation Resistance in Glioblastoma (part 2)
SUMMARY Despite numerous genome-wide association studies involving glioblastoma (GBM), few therapeutic targets have been identified for this disease. Using patient derived glioma sphere cultures (GSCs), we have found that a subset of the proneural (PN) GSCs undergo transition to a mesenchymal (MES)...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-49162 | biostudies-arrayexpress
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