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TranscriptomicsTranscription profiling time series of Rattus norvegicus Sertoli cells treated with follicle-stimulating hormone
Spermatogenesis requires the presence of functional somatic Sertoli cells in the seminiferous tubules of the testis. Sertoli cells provide support and factors necessary for the successful progression of germ cells into spermatozoa. Sertoli cells are regulated to a large degree by the glycoprotein ho...
ORGANISM(S): Rattus norvegicus 
2007-12-12 | E-GEOD-509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of G sulfurreducens GGS Fe(III) vs fumarate
G. sulfurreducens (ATCC #51573) was obtained from the laboratory culture collection of Dr. Derek Lovley. Cells were grown under strict anaerobic conditions at 30 °C in chemostats, (see Esteve-Núñez, A., M. M. Rothermich, M. Sharma, and D. R. Lovley. 2004. Growth of Geobacter sulfurreducens under nut...
ORGANISM(S): Geobacter sulfurreducens 
2005-01-01 | E-TIGR-81 | biostudies-arrayexpress
TranscriptomicsTGFß1-driven epithelial to mesenchymal transition in human kidney cell line
TGFbeta is the major cytokine driver of fibrosis in the kidney and other tissue. Epithelial-mesenchymal transition has been postulated to contibrute to renal fibrosis in diseases such as diabetic nephropathy. We wished to identify novel genes that were upregulated in human kidney epithelial cells in...
ORGANISM(S): Homo sapiens 
2011-05-30 | E-GEOD-23338 | biostudies-arrayexpress
TranscriptomicsMyeloid lineage switch in pro-B cells generates novel macrophage subsets during homeostasis and inflammation
Here we demonstrate for the first time evidence of lineage switch from B-1 B lymphocyte to a macrophage , or so-called transdifferentiation, occurring in mature cells in vivo. Specifically, using transgenic B6.Mb1-iCre/Rosa26-YFP mice, in which YFP expression is restricted exclusively to B cell line...
ORGANISM(S): Mus musculus 
2018-09-01 | E-MTAB-1878 | biostudies-arrayexpress
TranscriptomicsMMP3 treatment of Panc-2 cells
Response of pancreas cancer cells to treatment with recombinant MMP3 Cells were treated with 100U/ml MMP3 for 4 days, then isolated for RNA. The submitted experiments represent two different experiments performed at different times
ORGANISM(S): Homo sapiens 
2014-05-29 | E-GEOD-50931 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Zbtb20-expressing Tregs against activated (CD62Llo) and naive (CD62Lhi) Tregs that do not express Zbtb20
The objective of this study was to determine if a subset of regulatory T cells (Tregs) expressing the transcription factor, Zbtb20, played a unique role in the function of the immune system. Genetic reporter mice were used to isolate Zbtb20-expressing Tregs as well as activated (CD62Llo) and naive (...
ORGANISM(S): Mus musculus 
2022-02-25 | E-MTAB-11442 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish embryos injected with Ofd1 morphlino compared to wild type
Comparison of Ofd1 morphlino injected zebrafish embryos with wild type
ORGANISM(S): Danio rerio 
2008-12-01 | E-MEXP-1879 | biostudies-arrayexpress
TranscriptomicsFine-tuning of human dendritic cells regulation revealed by translational profiling
Dendritic cells (DCs) are the sentinels of the mammalian immune system and they undergo a complex maturation process mediated by activation upon pathogen detection. Recent studies described the analysis of activated DCs by transcriptional profiling, but translation regulation was never taken in acco...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-14000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary microglial cultures with and without neurovirulent (FrCasE) and non-neurovirulent (Fr57E) virus infection
We undertook a survey of gene expression changes in primary microglial cultures with and without neurovirulent (FrCasE) and non-neurovirulent (Fr57E) virus infection to identify physiological changes that could be relevant to the induction of spongiform neurodegeneration. These gene expression analy...
ORGANISM(S): Mus musculus 
2005-05-11 | E-MEXP-459 | biostudies-arrayexpress
ProteomicsA pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011, 29(7):635-43. doi: 10.1038/nbt.1899. PMCID:PMC3366591. Discovery, AIMS, and MRM datasets Discovery_Tranche_hash: b/quYtp/Q8fY...
2013-12-19 | MSV000078513 | MassIVE
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