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TranscriptomicsNeurotrophin NT3 promotes ovarian primordial to primary follicle transition
Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and ...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20358 | biostudies-arrayexpress
TranscriptomicsComparison between HuT78 parental and romidpepsin-selected cell lines
Gene expression values were determined for HuT78 parental cells and cells selected with romidpesin in the presence of P-glycoprotein inhibitors. HuT78 DpVp35 cells are maintained in 35 ng/ml romidepsin with 2.5 µg/ml verapamil and HuT78 DpP100 cells are maintained in 100 ng/ml romidepsin with 1 µM v...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45018 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human epithelium-only colonic and small intestinal organoids derived from intestinal resections, biopsy specimens and cryopreserved crypts
Patient-derived gastrointestinal epithelium-only organoids from the small and large intestine, also referred to as colonoids and enteroids, were generated as part of the development of an on-going organoid biobank at the Michigan Medicine Translational Tissue Modeling Laboratory (TTML) (www.UmichTTM...
ORGANISM(S): Homo sapiens 
2020-07-24 | E-MTAB-9339 | biostudies-arrayexpress
UnknownManagement of Patients with Myocardial Injury After Noncardiac Surgery: A Retrospective Chart Review.
Not available
S-EPMC11763853 | biostudies-literature
Transcriptomicsexpression profiling data of CLB-GA neuroblastoma cells upon TAE-684, Crizotinib, X-396, LDK378, Trametinib, BEZ-235 and Vandetanib
Treatment of the CLB-GA cell line with complementary ALK, MEK, PI3K/mTOR or RET inhibitors (and DMSO (VWR) as control) was performed in duplicate for each drug using the GI50 concentrations (see further): 0.5M-k_M Crizotinib (Pfizer/Sigma-Aldrich); 0.06M-k_M X-396 (VWR); 0.2M-k_M LDK378 (Hoelzel Bio...
ORGANISM(S): homo sapiens 
2015-05-04 | E-MTAB-3206 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The exposure of a gestating female during the period of gonadal sex determination has been shown to promote sperm epimutations, diffe...
ORGANISM(S): Rattus norvegicus 
2012-09-27 | E-GEOD-41173 | biostudies-arrayexpress
TranscriptomicsDioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations
Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote e...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59552 | biostudies-arrayexpress
TranscriptomicsHydrocarbons (Jet Fuel JP-8) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats wer...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59553 | biostudies-arrayexpress
TranscriptomicsPesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a M-bM-^@M-^\pesticide mixtureM-bM-^@M-^] (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerationa...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59554 | biostudies-arrayexpress
TranscriptomicsPlastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1M-bM-^@M-^SF3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived en...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59555 | biostudies-arrayexpress
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