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TranscriptomicsTranslational profiling in the unfolded protein response
The unfolded protein response (UPR) couples cellular translation rates and gene expression to the protein folding status of the endoplasmic reticulum (ER). Upon activation, the UPR machinery elicits a general suppression of protein synthesis and activation of stress gene expression, which act coordi...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-53743 | biostudies-arrayexpress
ProteomicsNicchitta SILAC RNA binding Proteins
Quantitative LC-MS/MS was performed on 2.5 uL (6%) of each sample, using a nanoAcquity UPLC system (Waters Corp) coupled to a Thermo Orbitrap Fusion Lumos high resolution accurate mass tandem mass spectrometer (Thermo) equipped with a FAIMSPro device via a nanoelectrospray ionization source. Briefly...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-19 | MSV000088005 | MassIVE
TranscriptomicsDissection of the translational impacts of the PERK pathway
Disruptions of protein homeostasis in the endoplasmic reticulum (ER) elicit activation of the unfolded protein response (UPR), a translation- and transcription-coupled proteostatic stress response pathway. The primary translational control arm of the UPR is initiated by the PERK-dependent phosphoryl...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-68265 | biostudies-arrayexpress
TranscriptomicsRibosome profiling analysis of Dengue Virus
Dengue virus is an + strand RNA virus. We have carried our infections of human cells with Dengue and analyzed the translation, replication, and localization of the Dengue RNA. This allowed for clear definition of the life cycle of the Dengue virus inside a host cell. We also assessed the host respon...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-69602 | biostudies-arrayexpress
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