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ProteomicsProteome analysis of Mel426 melanoma cells with R2PD1 treatment
A label-free quantification experiment was performed to study the effect of R2PD1 chimeric protein treatment on the cellular proteome of Mel426 human melanoma cells. Peptides were separated by online reverse phase liquid chromatography and measured in an Exploris 480 Orbitrap mass spectrometer. Mas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-16 | MSV000091500 | MassIVE
TranscriptomicsGene expression changes in mouse embryonic fibroblasts (MEF cells) deficient for Ing1 and Gadd45a
ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We found that ING1b and GADD45a physically and functionally interact in the epigenetic regulation of specific target genes. In order to study this interaction further, we analysed the transcri...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-43318 | biostudies-arrayexpress
TranscriptomicsGadd45a and Ing1 interaction in epigenetic gene regulation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-02-04 | E-GEOD-43319 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcriptome analysis of neuron-enriched DRG cultures exposed to Wnt3a
To test the potential of canonical Wnt signalling to modulate nociception via transcriptional regulation in dorsal root ganglion (DRG) neurons, we performed a genome-wide transcriptome analysis of neuron-enriched DRG cultures treated with Wnt3a or vehicle for 6 hours. Total RNA obtained from neuron-...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-56880 | biostudies-arrayexpress
ProteomicsPolyubiquitination analysis upon GSK3 inhibition in HeLa cell extracts
HeLa cell extracts with or without GSK3 enzyme inhibition were assayed using protein microarrays in order to detect GSK3-dependent changes in protein polyubiquitination. HeLa lysates in triplicates were supplemented with ubiquitin and incubated on protein microarrays (ProtoArray 5.0; Invitrogen) in ...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-50629 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Wnt3a-treated HeLa cells in G1 and G2/M phase
The early transcriptional response of HeLa cervical carcinoma cells to the canonical Wnt signalling pathway was investigated at two different cell cycle phases (G1 and G2/M) via microarray gene expression profiling. HeLa cells grown under standard conditions were treated for 3 h with either Control,...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-50248 | biostudies-arrayexpress
TranscriptomicsFate specification of neural plate border by canonical Wnt signaling and Grhl3 is crucial for neural tube closure.
During primary neurulation, the separation of a single-layered ectodermal sheet into the surface ectoderm (SE) and neural tube specifies SE and neural ectoderm (NE) cell fates. The mechanisms underlying fate specification in conjunction with neural tube closure are poorly understood. Here, by compar...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-67977 | biostudies-arrayexpress
GenomicsEnhancers reside in a unique epigenetic environment during early development
During development and differentiation, enhancers, and not promoters are most dynamic in their DNA methylation status. However, the causal relationship between enhancer activity and methylation is not clear. Here, we describe that during early zebrafish development, enhancer activity has little infl...
ORGANISM(S): Danio rerio 
2015-11-09 | E-GEOD-74789 | biostudies-arrayexpress
TranscriptomicsDickkopf 3 Promotes the Differentiation of Substantia Nigra Dopaminergic Neurons In Vivo and from Pluripotent Stem Cells In Vitro
WNT1/beta-catenin signaling plays a crucial role in the generation of mesodiencephalic dopaminergic (mdDA) neurons including the Substantia nigra pars compacta (SNc) subpopulation, whose degeneration is a hallmark of Parkinson’s Disease (PD). However, the precise functions of WNT/beta-catenin signal...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-58813 | biostudies-arrayexpress
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