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TranscriptomicsLipoic acid prevents Cr6+ induced cell transformation and the associated genomic dysregulation.
Investigation of the transcription profile of cells transformed by Cr6+ in vivo was undertaken. The objective was to elucidate genomic changes underlying the mechanism of action of the carcinogenic dose of Cr6+and their prevention using metabolic antioxidant Lipoic acid (LA). Cr6+ was administered i...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-41419 | biostudies-arrayexpress
TranscriptomicsERK activation, gene dysregulations and cell transformation at submicromolar doses of Cr6+ in C3H10T1/2 and BALB/c 3T3 cells: interaction with Lipoic acid
The molecular mechanism of Cr6+ carcinogenicity is not well understood. Studies advocate a key involvement of the altered cytogenomics and dysregulated pathways in Cr6+ toxicity. However, the dissimilarity in expression of genes and pathways in cells transformed by Cr6+ has led us to supplement more...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-43156 | biostudies-arrayexpress
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