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GenomicsSox2-regulatory networks in embryonic and trophoblast stem cells.
Sox2 is a pleiotropic transcription factor that regulates self-renewal and differentiation capacity in different types of stem cells, raising the possibility that it regulates similar transcriptional programs controlling common stemness. Embryonic stem (ES) cells and trophoblast stem (TS) cells are ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28455 | biostudies-arrayexpress
GenomicsDynamics of Sox2 occupancy during the differentiation of embryonic stem cells into trophoblast stem cells.
To understand the mechanism underlying the versatility in transcriptional regulation by Sox2, we compared genome-wide binding sites of Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). A tetracycline-...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28453 | biostudies-arrayexpress
TranscriptomicsConditional knockout of Sox2 in embryonic and trophoblast stem cells.
To compare the transcriptional networks governed by Sox2 in embryonic stem (ES) cells and trophoblast stem (TS) cells, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Sox2 in each cell type. A Tet-inducible Sox2 knockout ES cell line 2TS22C or its derivativ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28451 | biostudies-arrayexpress
TranscriptomicsInduction of trophoblast stem cells from embryonic stem cells by forced repression of Oct3/4.
To characterize the transdifferentiation of embryonic stem (ES) cells into trophoblast stem (TS) cells triggered by forced repression of Oct3/4, we performed whole-genome expression analysis after tetracycline (Tet)-induced knockout of Oct3/4. A Tet-inducible Oct3/4 knockout ES cell line ZHBTc4 was ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-28452 | biostudies-arrayexpress
TranscriptomicsQuartz-Seq: a simple and highly quantitative method for single-cell RNA-Seq
We report novel single-cell RNA-Seq, called Quartz-Seq. Quartz-Seq was simplified method compared with previous methods based on poly-A tailing reaction. RNA-seq by illumina TruSeq, KAPA library preparation kit, single-cell Quartz-Seq and single-cell Smart-Seq by illumina HiSeq 2000/1000
ORGANISM(S): Mus musculus 
2013-04-04 | E-GEOD-42268 | biostudies-arrayexpress
TranscriptomicsExpression profile of adult mouse 51 CNS regions
The adult mammalian brain is composed of distinct regions that have specialized roles. To dissect molecularly this complex structure, we conducted a project, named the BrainStars (B*) project, in which we sampled ~50 small brain regions, including sensory centers and centers for motion, time, memory...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-16496 | biostudies-arrayexpress
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