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TranscriptomicsShared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma of the extremities
Soft tissue sarcoma diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC-arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extre...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-13775 | biostudies-arrayexpress
TranscriptomicsGenomic profiling of colorectal cancer from patients with Lynch syndrome and Familial colorectal cancer type X with comparison to sporadic microsatelite stable and instable colorectal cancer
Lynch syndrome and Familial colorectal cancer type X (FCCTX) are clinically diagnosed using the same criteria, but genomic differences exist between these two groups and the genomic profiles share similarities with their sporadic counterparts, mismatch repair (MMR) deficient and proficient tumors, r...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-38405 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of primary and secondary angiosarcomas using RNA extracted from formalin-fixed parafinembedded samples.
Angiosarcomas are highly malignant tumors that develop as primary angiosarcomas of unknown cause or as secondary angiosarcomas, most often following radiation therapy for breast cancer. These subsets are morphologically indistinguishable, which motivates our aim to identify genetic classifiers for d...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-52664 | biostudies-arrayexpress
TranscriptomicsMolecular subtyping of serous ovarian tumors reveals multiple connections to intrinsic breast cancer subtypes
Epithelial ovarian cancer is morphologically and clinically heterogeneous. Transcriptional profiling has revealed molecular subtypes (referred to as M-bM-^@M-^\C-signaturesM-bM-^@M-^]) that correlate to biological as well as clinical features. We aimed to determine gene expression differences betwee...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-GEOD-57477 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles in ovarian cancer linked to Lynch syndrome
Heredity is a major cause of ovarian cancer. Lynch syndrome is associated with 10-12% risk of ovarian cancer, diagnosis at young age and a predilection for endometrioid and clear cell tumors. Global gene expression profiling applied to 25 Lynch syndrome-associated and 42 sporadic ovarian cancers rev...
ORGANISM(S): Homo sapiens 
2013-10-14 | E-GEOD-37394 | biostudies-arrayexpress
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