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TranscriptomicsMurine regulatory T cells stimulated by death receptor 3 agonistic antibody
CD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft and host disease (GVHD) in murine models of allogeneic hematopoietic cell transpl...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-83743 | biostudies-arrayexpress
TranscriptomicsHes1 is responsible for Notch signaling-mediated suppression of acute myeloid leukemia development
In leukemogenesis Notch signaling can be up- and down-regulated in a context-dependent manner. Here we report that deletion of hairy and enhancer of split-1 (Hes1) promotes acute myeloid leukemia (AML) development induced by the MLL-AF9 fusion protein. Subsequently, the FMS-like tyrosine kinase 3 (F...
ORGANISM(S): Mus musculus 
2017-05-02 | E-GEOD-50234 | biostudies-arrayexpress
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