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TranscriptomicsExpression profiles of immortal lung fibroblasts
Activation of telomerase often endows cancer cells, but rarely normal somatic cells, with immortality. Especially, fetal lung fibroblasts are known to be hardly immortalized by TERT overexpression. We here established an immortal non-transformed lung fibroblast cell line only by TERT transfection, a...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-9077 | biostudies-arrayexpress
TranscriptomicsSelf-organization of polarized cerebellar plate neuroepithelium in three-dimensional culture of human pluripotent stem cells
During cerebellar development, the main portion of the cerebellar plate neuroepithelium (NE) gives birth to Purkinje cells and interneurons, while the germinal zone at its dorsal edge, called the rhombic lip (RL), generates granule cells and cerebellar nuclei neurons. However, it remains elusive how...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-63015 | biostudies-arrayexpress
TranscriptomicsVulnerability of Purkinje cells induced from spinocerebellar ataxia type 6 patient-derived iPS cells [1]
Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, ?1A subunit of P/Q-type calcium channel. However, the pathogenic ...
ORGANISM(S): Homo sapiens 
2016-11-08 | E-GEOD-85347 | biostudies-arrayexpress
TranscriptomicsChemosensitivity prediciton in esophageal cancer cell line using cDNA microarray
A total of 20 KYSE human esophageal squamous cell carcinoma cell lines (KYSE-30, -140, -150, -170, -180, -200, -220, -350, -410, -450, -510, -520, -590, -770, -850, -890, -1170, -1190, -1250, and -2270) and a non-cancerous esophageal epithelial cell (HEEC-1)were kindly provided by Dr. Y. Shimada (Ky...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-2454 | biostudies-arrayexpress
TranscriptomicsChemosensitivity prediction in esophageal cancer cell line using oligonucleotide array
A total of 20 KYSE human esophageal squamous cell carcinoma cell lines (KYSE-30, -140, -150, -170, -180, -200, -220, -350, -410, -450, -510, -520, -590, -770, -850, -890, -1170, -1190, -1250, and -2270) were kindly provided by Dr. Y. Shimada (Kyoto University, Kyoto, Japan). The KYSE cell lines wer...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-2447 | biostudies-arrayexpress
TranscriptomicsEffect of locally applied enalapril maleate on the gene expression profile in dorsal skin after UVB irradiation
Renin-angiotensin system regulates cell proliferation, differentiation, apoptosis and tissue remodeling in skin. Previouly, we reported that angiotensin-converting enzyme (ACE) expression and angiotensin II level were enhanced by repeated UVB-irradiation of hairless mice skin, and ACE inhibitor enal...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-61708 | biostudies-arrayexpress
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