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MetabolomicsNitrate-Sialin2 Axis Couples ER-Mitochondrial Calcium Signaling with Fatty Acid Metabolism to Drive White Adipose Browning
Nutrient cues shape adipose homeostasis; however, the mechanism by which inorganic signals engage organelle networks to drive white fat browning remains unclear. Here, we identify a nitrate-Sialin2 pathway that converts dietary nitrate into a spatially confined thermogenic program. Sialin2 localizes...
2026-05-17 | MTBLS14192 | MetaboLights
TranscriptomicsExpressionprofiling of a glnR-mutant of Mycobacterium tuberculosis during culture on nitrate
Identification of glnR-dependent regulation of nitrate assimilation Keywords: genetic modification Mycobacterium tuberculosis H37Rv wild type and glnR mutant strain were incubated in minimal medium supplemented with 5 mM NO3 for 18 and 48 hours. RNA was extracted at indicated time points and microa...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2010-06-20 | E-GEOD-13246 | biostudies-arrayexpress
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
ProteomicsInteractome of the Escherichia coli nitrate reductase respiratory complex, NarGHI, under various metabolic conditions
Cellular respiration is a fundamental process undergone within energy-transducing membranes through the redox activity of multimeric protein assemblies, so-called respiratory complexes. In most cases, electron transport is ensured by lipophilic molecules, quinones, serving as electron shuttles. This...
ORGANISM(S): Escherichia coli 
2019-10-07 | PXD012320 | Pride
Narghi Escherichia coli Nitrate respiration Label-free Interactome 
ProteomicsFe(III) Mineral Encrustation Uncouples Respiration from Reproduction of the Nitrate-Reducing Fe(II)-Oxidizing bacterium Acidovorax sp. BoFeN1
Fe(II) can be oxidized by mixotrophic nitrate-reducing Fe(II)-oxidizing bacteria to Fe(III), leading to mineral precipitation. However, the effects of this process on the metabolism and reproduction ability of the Fe(II)-oxidizing bacterial cells have not yet been quantified. In this study, we inves...
ORGANISM(S): Acidovorax 
2026-01-01 | PXD072688 |
TranscriptomicsIdentification of genes induced on nitrate, role of OxyR
The study aimed to identify role of OxyR during growth on different electron acceptors when E. coli are growing anaerobically. Wt and OxyR null cells were grown on nitrate and fumarate medium anaerobically. Each condition was done in duplicate. RNA was extracted using Qiagen RNeasy kit after stabili...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-05-02 | E-GEOD-24524 | biostudies-arrayexpress
TranscriptomicsMR-1 nitrate sample to fumarate sample
One of the most striking observations in the S. oneidensis genome regarding nitrate respiration is that napC is missing and nrfBCD is degenerated. To gain insights into candidate genes encoding the protein(s) in place of NapC and NrfBCD function, i.e., delivering electrons to NapA and NrfA, transcri...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-05-19 | E-GEOD-11198 | biostudies-arrayexpress
TranscriptomicsFermentative and nitrate respiratory transcriptome analysis of E. coli K12 MG1655
Determining how facultative anaerobic organisms sense and direct cellular responses to electron acceptor availability has been a subject of intense study. However, even in the model organism Escherichia coli, established mechanisms only explain a small fraction of the hundreds of genes that are regu...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-02-27 | E-GEOD-55365 | biostudies-arrayexpress
TranscriptomicsM. tuberculosis (Mtb) Produces Nitrite in Human Macrophages in Physiologic Oxygen to Impact Mycobacterial ATP Consumption and Gene Expression
We sequenced mRNA from Mtb that had been treated with 5 mM nitrate or was untreated in standard 7H9/ADNaCl medium. This generated the first analysis of gene expression following mycobacterial nitrate respiration. Examination of mRNA levels in Mtb following nitrate respiration, which results in the p...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-10-21 | E-GEOD-51037 | biostudies-arrayexpress
TranscriptomicsThe conserved 3’ UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration
In pursuit of a biological role of Salmonella 3' UTR derived sRNA NarS ,we sought to determine potential target mRNAs of NarS under anaerobic conditions. To this end, we compared gene expression in NarS-deficient and NarS overexpression (from plasmid pPL-NarS) strains following a 30-minute anaerobic...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2019-08-22 | E-MTAB-8244 | biostudies-arrayexpress
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