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MetabolomicsMetabolomic Analysis of Fission Yeast at the Onset of Nitrogen Starvation
Microorganisms naturally respond to changes in nutritional conditions by adjusting their morphology and physiology. The cellular response of the fission yeast S. pombe to nitrogen starvation has been extensively studied. Here, we report time course metabolomic analysis during one hour immediately af...
2013-11-26 | MTBLS67 | MetaboLights
MetabolomicsRapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats
INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of...
2020-06-11 | MTBLS804 | MetaboLights
MetabolomicsLegume rhizodeposition promotes nitrogen fixation by soil microbiota under crop diversification

Biological nitrogen fixation by free-living bacteria and rhizobial symbiosis with legumes plays a key role in sustainable crop production. Here, we study how different crop combinations influence the interaction between peanut plants and their rhizosphere microbiota via metabolite deposition and ...

2024-03-19 | MTBLS6537 | MetaboLights
MetabolomicsElevated temperature accelerates leaf senescence and promotes leaf nitrogen transport to improve rice grain protein synthesis
Elevated temperatures during grain filling severely constrain rice yield and quality. Although additional nitrogen can mitigate the adverse effects of elevated temperature, both factors increase grain protein content, and the underlying physiological mechanisms remain poorly understood. Here, we con...
2026-06-17 | MTBLS14777 | MetaboLights
MetabolomicsMechanism of Pediococcus acidilacticus YH-15 on Fat Reduction

Obesity and related metabolic syndromes pose a growing global health challenge, increasingly linked to severe complications including cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. High-fat diet (HFD) serves as a key environmental driver of obesity, disrupting gut...

2026-01-04 | MTBLS13595 | MetaboLights
MetabolomicsAssessing the impact of nitrogen supplementation in oats across multiple growth locations and years with targeted phenotyping and high-resolution metabolite profiling approaches
Oats (Avena sativa L.) are a healthy food, being high in dietary fibre (e.g. β-glucans), antioxidants, minerals, and vitamins. Understanding the effect of variety and crop management on nutritional quality is important. The response of four oat varieties to increased nitrogen levels was investigated...
2021-04-26 | MTBLS1801 | MetaboLights
MetabolomicsAspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primary aspartate aminotransferase of M. tuberculosis...

2020-05-01 | MTBLS1559 | MetaboLights
MetabolomicsTranscriptomic and lipidomic profiling of subcutaneous and visceral adipose tissues in 15 vertebrates
The storage of lipids as energy in adipose tissue (AT) has been conserved over the course of evolution. However, substantial differences in ATs physiological activities were reported between species. Hence, establishing the mechanisms shaping evolutionarily divergence in ATs transcriptomes could pro...
2022-11-17 | MTBLS5943 | MetaboLights
MetabolomicsCoupled nitrogen fixation and substrate stabilization drive ecological strategy shifts during microbial succession

Background:

Primary succession is predicted to proceed through shifts from stress-tolerant to competitive to cooperative ecological strategies as resource availability increases, yet molecular evidence for these transitions in microbial systems remains limited. Here, we used an integrated m...

2026-03-12 | MTBLS14041 | MetaboLights
MetabolomicsArsenic-induced enhancement of diazotrophic recruitment and nitrogen fixation in Pteris vittata rhizosphere
Heavy metal contamination poses an escalating global challenge to soil ecosystems. Hyperaccumulators play a crucial role in environmental remediation and resource recovery. The enrichment of diazotrophs and resulting nitrogen accumulation promoted hyperaccumulator growth and facilitated phytoremedia...
2024-11-01 | MTBLS11419 | MetaboLights
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