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MetabolomicsFunctional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights
TranscriptomicsEffect of Th-POK deficiency on global gene expression in liver Va14i NKT cells
We sought to identify genes regulated by the transcription factor Th-POK (Zbtb7b) in liver Va14i NKT cells, by RNA microarray analysis of global gene expression in Va14i NKT cells from mice homozygous for the Th-POK-inactivating hd point mutation as compared with the same cell population isolated fr...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-34179 | biostudies-arrayexpress
GenomicsGenome-wide maps of Egr2 transcription factor binding sites in NKT and anti TCRb injected thymocytes.
We report the application of single-molecule-based sequencing technology for mapping the Egr2 transcriptional program in developing thymic NKT. We found that Egr2 controls the induction of genes required for NKT development. Examination of developing NKT cells and thymocytes receiving a strong TCR s...
ORGANISM(S): Mus musculus 
2012-02-06 | E-GEOD-34254 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profiling of NKT and MAIT subsets in different organs of B6-MAIT/CAST mice.
MAIT cells (MAITs) represent an abundant T lymphocyte subset with unique specificity for microbial metabolites presented by the MHC-1b molecule, MR1. MAIT conservation along evolution indicates important, non-redundant functions, but their low frequency in mice has hampered their detailed characteri...
ORGANISM(S): Mus musculus 
2018-12-03 | E-MTAB-7133 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of wild-type and IL15ko thymic NKT cells
Semi-invariant natural killer T (NKT) cells are thymus-derived innate lymphocytes that modulate microbial and tumour immunity as well as autoimmune diseases. These immunoregulatory properties of NKT cells are acquired during their development. Much has been learnt regarding the molecular and cell...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-32568 | biostudies-arrayexpress
TranscriptomicsNKT-10 cells represent a novel invariant NKT cell subset with regulatory characteristics
We compared splenic Va14i NKT cells from C57BL/6 control mice and from mice injected 4 weeks earlier intravenously with 4ug/mouse of the iNKT cell antigen alpha-galactosylceramide (aGalCer). These mice were either left unstimulated or were stimulated with 1ug/mouse aGalCer i.v.. All mice were female...
ORGANISM(S): Mus musculus 
2014-07-25 | E-GEOD-47959 | biostudies-arrayexpress
TranscriptomicsMature thymic NKT and T cells
Invariant Natural killer T (iNKT) cells are a separate lineage of T lymphocytes with innate effector functions. They express an invariant TCR specific for lipids presented by CD1d and their development and effector differentiation rely on a unique gene expression program. We asked whether this progr...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-15925 | biostudies-arrayexpress
TranscriptomicsExpression data from CD1d tetramer-sorted b-GL122/LGL1–specific human T cells or iNKT cells
The ability to detect and isolate bGL1-22/LGL1–specific human type II NKT cells allowed us to compare the global gene expression profiles of these cells with type I NKT cells using microarray analysis. Principal component analysis revealed that the gene expression profile signature for bGL1-22 and...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-77909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse innate lymphocyte cells lines containing B1-B, NKT, CD8aaT cells and adaptive B2-B, CD4T, CD8abT cells cell-types sorted by FACS
Three innate (B1-B, NKT, CD8aaT cells) and adaptive (B2-B, CD4T, CD8abT cells) cell-types were sorted by FACS. Three biological replicates for NKT, CD4T, CD8aaT, CD8abT cells and two biological replicates for B1 and B2 cells were generated and the expression profiles were determined using Affymetri...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3039 | biostudies-arrayexpress
TranscriptomicsExpression data comparing PLZF+/+, PLZF +/lu, PLZF lu/lu gammadelta NKT cells
Natural killer (NKT) T cells exhibit tissue distribution, surface phenotype, and functional responses that are strikingly different from those of conventional T cells. The transcription factor PLZF is responsible for most of these properties, as its ectopic expression in conventional T cells is suff...
ORGANISM(S): Mus musculus 
2012-11-09 | E-GEOD-42168 | biostudies-arrayexpress
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