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MetabolomicsApplication of 1H-NMR Metabolomic Profiling for Reef-Building Corals
In light of global reef decline new methods to accurately, cheaply, and quickly evaluate coral metabolic states are needed to assess reef health. Metabolomic profiling can describe the response of individuals to disturbance (i.e., shifts in environmental conditions) across biological models and is a...
2014-11-20 | MTBLS116 | MetaboLights
MetabolomicsNMR Metabolomics in Frailty disease

Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of a well-characterized cohort of elderly subjects encompassing the whole fit-to-frail continuum. Enrichment analyses revealed a complex dysregula...

2024-11-08 | MTBLS11188 | MetaboLights
MetabolomicsNMR-based metabolic profiling of children with premature adrenarche

INTRODUCTION: Premature adrenarche (PA) for long time was considered a benign condition but later has been connected to various diseases in childhood and adulthood which remains controversial.

OBJECTIVE: To investigate the effect of premature adrenarche ...

2022-10-18 | MTBLS2387 | MetaboLights
MetabolomicsDetection Limits of Blood Metabolites at Physiological Concentrations Using Benchtop 1H NMR

Commercial low-field (LF) magnetic resonance spectroscopy (MRS) offers a route to rapid and repeated \textit{in vivo} metabolite tracking, however its sensitivity and interpretability at physiological concentrations remain underexplored. Here we evaluate the performance of an 80 MHz benchtop nucl...

2025-12-29 | MTBLS6262 | MetaboLights
MetabolomicsA Metabonomic Comparison of Human Serum and Plasma Subtypes Using Untargeted NMR Spectroscopy and UPLC-MS (NMR assays)
INTRODUCTION: Differences in the metabolite profiles between serum and plasma are incompletely understood. OBJECTIVES: To evaluate metabolic profile differences between serum and plasma and among plasma sample subtypes. METHODS: We analyzed serum, platelet rich plasma (PRP), platelet poo...
2018-07-25 | MTBLS470 | MetaboLights
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
MetabolomicsNMR- and LC–MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice (NMR assay)
In the present study, both untargeted and targeted metabolomics approaches were used to evaluate the subacute effects of hexabromocyclododecane (HBCD) on mice urine metabolome. Untargeted metabolomics based on 1H NMR showed that HBCD exposure disturbed mice metabolism in both dosed groups, especiall...
2015-02-14 | MTBLS166 | MetaboLights
MetabolomicsEvaluation of sample preparation protocols for quantitative NMR-based metabolomics

INTRODUCTION: Quantification of metabolites in biological fluids and tissues by NMR spectroscopy is challenged by the presence of abundant macromolecules and lipoproteins in samples, which give broad signals in the NMR spectra. To improve the quality of NMR spectra the different ...

2024-07-11 | MTBLS847 | MetaboLights
MetabolomicsAn NMR metabolomics analysis pipeline for human neutrophil samples with limited source material
Untargeted 1H NMR metabolomics is a robust and reproducible approach to study metabolism in biological samples, providing unprecedented insight into altered cellular processes associated with human diseases. Metabolomics is increasingly used alongside other -omics techniques, such as proteomics and ...
2025-11-06 | MTBLS6220 | MetaboLights
Metabolomics1H NMR-Based Plasma Metabolomics and Machine Learning Reveal Distinct Metabolic Signatures of Breast Cancer in Nigerian Women

Metabolic dysregulation is a hallmark of cancer and provides insights into biomarker discovery. Untargeted 1H NMR metabolomics offers a non-invasive means to identify biomarkers in breast cancer (BC) patients; however, metabolic signatures specific to Nigerian women remain poorly understood. This...

2026-02-23 | MTBLS13829 | MetaboLights
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