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MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
MetabolomicsEvaluation of sample preparation protocols for quantitative NMR-based metabolomics

INTRODUCTION: Quantification of metabolites in biological fluids and tissues by NMR spectroscopy is challenged by the presence of abundant macromolecules and lipoproteins in samples, which give broad signals in the NMR spectra. To improve the quality of NMR spectra the different ...

2024-07-11 | MTBLS847 | MetaboLights
MetabolomicsRANCM: a new ranking scheme for assigning confidence levels to metabolite assignments in NMR-based metabolomics studies

INTRODUCTION: The Metabolomics Standards Initiative has recommended four categories for metabolite assignments in NMR-based metabolic profiling studies. The putatively annotated compound category is most commonly reported by metabolomics investigators. However, there is significa...

2019-09-27 | MTBLS781 | MetaboLights
MetabolomicsComparison of Chemical Compositions in Pseudostellariae Radix from Different Cultivated Fields and Germplasms by NMR-Based Metabolomics
Pseudostellariae Radix (PR) is an important traditional Chinese medicine (TCM), which is consumed commonly for its positive health effects. However, the chemical differences of PR from different cultivated fields and germplasms are still unknown. In order to comprehensively compare the chemical comp...
2018-01-25 | MTBLS399 | MetaboLights
MetabolomicsDeciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic ...

2021-08-03 | MTBLS981 | MetaboLights
MetabolomicsCASMDB: An Open-Source Database of Metabolite Annotation Data for 1D 1 H NMR-Based Metabolomics
In metabolomics analyses, databases are invaluable for the identification of individual metabolites in experimentally collected samples. Publicly available databases for NMR-based metabolomics are unfortunately incomplete with respect to experimental conditions, such as pH, temperature, and NMR fiel...
2026-04-21 | MTBLS6263 | MetaboLights
MetabolomicsNMR- and LC–MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice (NMR assay)
In the present study, both untargeted and targeted metabolomics approaches were used to evaluate the subacute effects of hexabromocyclododecane (HBCD) on mice urine metabolome. Untargeted metabolomics based on 1H NMR showed that HBCD exposure disturbed mice metabolism in both dosed groups, especiall...
2015-02-14 | MTBLS166 | MetaboLights
MetabolomicsNMR-based metabolic profiling of children with premature adrenarche

INTRODUCTION: Premature adrenarche (PA) for long time was considered a benign condition but later has been connected to various diseases in childhood and adulthood which remains controversial.

OBJECTIVE: To investigate the effect of premature adrenarche ...

2022-10-18 | MTBLS2387 | MetaboLights
MetabolomicsEvaluation of Sample Preparation Methods for the Analysis of Reef-Building Corals Using 1H-NMR-based Metabolomics
The field of metabolomics generally lacks standardized methods for the preparation of samples prior to analysis. This is especially true for metabolomics of reef-building corals, where the handful of studies that have been published employ a range of sample preparation protocols. The utilization of ...
2019-03-20 | MTBLS862 | MetaboLights
MetabolomicsNMR-Based Metabolomics of Non-Human Primate Ocular Tissues: A Dataset
Model animals are employed in experiments as substitutes for human tissues and fluids, particularly when accessing particular human samples (such as cerebrospinal fluid, brain, ocular tissues, etc.) poses significant challenges or is ethically constrained. Nonhuman primates are frequently regarded a...
2023-11-16 | MTBLS8943 | MetaboLights
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